Viral vectors have been used for a broad spectrum of gene therapy for both acute and
chronic diseases. In the context of cancer gene therapy, viral vectors expressing anti-tumor …

Gene therapy is a technique involving the modification of an individual's genes for treating a
particular disease. The key to effective gene therapy is an efficient carrier delivery system …

Therapeutic strategies based on modulation of microRNA (miRNA) activity hold great
promise due to the ability of these small RNAs to potently influence cellular behavior. In this …

Applications of viral vectors have found an encouraging new beginning in gene therapy in
recent years. Significant improvements in vector engineering, delivery, and safety have …

Tumor growth and progression rely upon angiogenesis, which is regulated by pro-and
antiangiogenic factors, including members of the semaphorin family. By analyzing 3 different …

Over just a single decade, we have witnessed the rapid maturation of the field of RNA
interference—the sequence-specific gene silencing mediated by small double-stranded …

Adeno-associated viral vectors (AAVs) have demonstrated potential in applications for
neurologic disorders, and the discovery that some AAVs can cross the blood-brain barrier …

Hyperactivity of the Myc oncogenic transcription factor dramatically reprograms gene
expression to facilitate cellular proliferation and tumorigenesis. To elicit these effects, Myc …

Efficient and specific delivery of genes to the cell type of interest is a crucial issue in gene
therapy. Adeno-associated virus (AAV) has gained particular interest as gene vector recently …

There is no effective treatment for late stage and metastatic cancers of colorectal, prostate,
pancreatic, breast, glioblastoma and melanoma cancers. Novel treatment modalities are …