Congenital hypogonadotropic hypogonadism (CHH) is a rare disorder caused by the
deficient production, secretion or action of gonadotropin-releasing hormone (GnRH), which …

BACKGROUND The discovery of kisspeptin as key central regulator of GnRH secretion has
led to a new level of understanding of the neuroendocrine regulation of human reproduction …

Abstract Cosponsoring Associations: The American Society for Reproductive Medicine, the
European Society of Endocrinology, and the Pediatric Endocrine Society. This guideline was …

BACKGROUND Kisspeptin is a key regulator of hypothalamic gonadotropin-releasing
hormone (GnRH) neurons and is essential for reproductive health. A specific kisspeptin …

Gonadotropin hormone-releasing hormone (GnRH) is the key regulator of the reproductive
axis. Its pulsatile secretion determines the pattern of secretion of the gonadotropins follicle …

Kisspeptin (KP) and neurokinin B (NKB) are neuropeptides that govern the reproductive
endocrine axis through regulating hypothalamic gonadotropin-releasing hormone (GnRH) …

Kisspeptin has recently emerged as a key regulator of the mammalian reproductive axis. It is
known that kisspeptin, acting centrally via the kisspeptin receptor, stimulates secretion of …

BACKGROUND Reproductive function is tightly regulated by nutritional status. Indeed, it has
been well described that undernutrition or obesity can lead to subfertility or infertility in …

Hypothalamic amenorrhoea (HA) accounts for approximately 30% of cases of secondary
amenorrhoea in women of reproductive age. It is caused by deficient secretion of …

Background Kisspeptin is the leading upstream regulator of pulsatile and surge
Gonadotrophin-Releasing Hormone secretion (GnRH) in the hypothalamus, which acts as …