Although discovered long ago, posttranslational phosphorylation of histones has been in the
spotlight only recently. Information is accumulating almost daily on phosphorylation of …

Granzyme A, a serine protease in the cytotoxic granules of natural killer cells and cytotoxic T
lymphocytes, induces caspase-independent cell death when introduced into target cells by …

Protein-protein interaction maps provide a valuable framework for a better understanding of
the functional organization of the proteome. To detect interacting pairs of human proteins …

Macroautophagy/autophagy deficit induces intracellular MAPT/tau accumulation, the
hallmark pathology in Alzheimer disease (AD) and other tauopathies; however, the reverse …

Granzyme A (GzmA) induces a caspase-independent cell death pathway characterized by
single-stranded DNA nicks and other features of apoptosis. A GzmA-activated DNase …

The Apaf‐1 apoptosome is a multi‐subunit caspase‐activating scaffold that is assembled in
response to diverse forms of cellular stress that culminate in apoptosis. To date, most studies …

In adult planarians, the replacement of cells lost to physiological turnover or injury is
sustained by the proliferation and differentiation of stem cells known as neoblasts. Neoblast …

The mechanisms of pathology for the family of polyglutamine disease proteins are unknown;
however, recently it was shown that several of these proteins inhibit transcription suggesting …

During the early phase of infection, the E1B-55K protein of adenovirus type 5 (Ad5) counters
the E1A-induced stabilization of p53, whereas in the late phase, E1B-55K modulates the …

The cytolytic T lymphocyte protease granzyme A (GzmA) initiates a caspase-independent
cell death pathway. Here we report that the rate-limiting enzyme of DNA base excision …