IL-6 and IL-8: an overview of their roles in healthy and pathological pregnancies

A Vilotić, M Nacka-Aleksić, A Pirković… - International journal of …, 2022 - mdpi.com
Interleukin-6 (IL-6) is an acknowledged inflammatory cytokine with a pleiotropic action,
mediating innate and adaptive immunity and multiple physiological processes, including …

Sex differences in innate and adaptive immunity impact fetal, placental, and maternal health

KJ Baines, RC West - Biology of reproduction, 2023 - academic.oup.com
The differences between males and females begin shortly after birth, continue throughout
prenatal development, and eventually extend into childhood and adult life. Male embryos …

[HTML][HTML] Pre-pregnancy obesity is associated with greater systemic inflammation and increased risk of antenatal depression

L Sominsky, M O'Hely, K Drummond, S Cao… - Brain, Behavior, and …, 2023 - Elsevier
Background Pre-pregnancy obesity is an emerging risk factor for perinatal depression.
However, the underlying mechanisms remain unclear. We investigated the association …

Immune alterations in recurrent implantation failure

N Mukherjee, R Sharma, D Modi - American Journal of …, 2023 - Wiley Online Library
A failure to achieve pregnancy after three or more embryo transfer cycles with high‐quality
blastocysts is referred to as recurrent implantation failure (RIF). RIF can be due to altered …

Human plasma proteome during normal pregnancy

AL Tarca, R Romero, G Bhatti, F Gotsch… - Journal of proteome …, 2022 - ACS Publications
The human plasma proteome is underexplored despite its potential value for monitoring
health and disease. Herein, using a recently developed aptamer-based platform, we profiled …

Cross-generational impact of innate immune memory following pregnancy complications

NA Lodge-Tulloch, AJ Toews, A Atallah, T Cotechini… - Cells, 2022 - mdpi.com
Pregnancy complications can have long-term negative effects on the health of the affected
mothers and their children. In this review, we highlight the underlying inflammatory …

Breast cancers co-opt normal mechanisms of tolerance to promote immune evasion and metastasis

LS Crump, KT Kines, JK Richer… - American Journal of …, 2022 - journals.physiology.org
Normal developmental processes, such as those seen during embryonic development and
postpartum mammary gland involution, can be reactivated by cancer cells to promote …

ALASCA: an R package for longitudinal and cross-sectional analysis of multivariate data by ASCA-based methods

AH Jarmund, TS Madssen… - Frontiers in Molecular …, 2022 - frontiersin.org
The increasing availability of multivariate data within biomedical research calls for
appropriate statistical methods that can describe and model complex relationships between …

Biomarkers of environmental enteric dysfunction and adverse birth outcomes: An observational study among pregnant women living with HIV in Tanzania

MA Kirby, JM Lauer, A Muhihi, N Ulenga, S Aboud… - …, 2022 - thelancet.com
Background Environmental enteric dysfunction (EED) may contribute to adverse birth
outcomes in low-resource settings. We examined the associations of EED biomarkers with …

Setting a stage: Inflammation during preeclampsia and postpartum

O Herrock, E Deer, B LaMarca - Frontiers in Physiology, 2023 - frontiersin.org
Preeclampsia (PE) is a leading cause of maternal and fetal mortality worldwide. The immune
system plays a critical role in normal pregnancy progression; however, inappropriate …