Pseudomonas aeruginosa: pathogenesis, virulence factors, antibiotic resistance, interaction with host, technology advances and emerging therapeutics
Pseudomonas aeruginosa (P. aeruginosa) is a Gram-negative opportunistic pathogen that
infects patients with cystic fibrosis, burn wounds, immunodeficiency, chronic obstructive …
infects patients with cystic fibrosis, burn wounds, immunodeficiency, chronic obstructive …
Antimicrobial resistance in ESKAPE pathogens
Antimicrobial-resistant ESKAPE (E nterococcus faecium, S taphylococcus aureus, K
lebsiella pneumoniae, A cinetobacter baumannii, P seudomonas aeruginosa, and E …
lebsiella pneumoniae, A cinetobacter baumannii, P seudomonas aeruginosa, and E …
Antidepressants can induce mutation and enhance persistence toward multiple antibiotics
Antibiotic resistance is an urgent threat to global health. Antidepressants are consumed in
large quantities, with a similar pharmaceutical market share (4.8%) to antibiotics (5%). While …
large quantities, with a similar pharmaceutical market share (4.8%) to antibiotics (5%). While …
Potentiating hypoxic microenvironment for antibiotic activation by photodynamic therapy to combat bacterial biofilm infections
Traditional antibiotic treatment has limited efficacy for the drug-tolerant bacteria present in
biofilms because of their unique metabolic conditions in the biofilm infection …
biofilms because of their unique metabolic conditions in the biofilm infection …
Effect of tolerance on the evolution of antibiotic resistance under drug combinations
J Liu, O Gefen, I Ronin, M Bar-Meir, NQ Balaban - Science, 2020 - science.org
Drug combinations are widely used in clinical practice to prevent the evolution of resistance.
However, little is known about the effect of tolerance, a different mode of survival, on the …
However, little is known about the effect of tolerance, a different mode of survival, on the …
Persistent bacterial infections and persister cells
RA Fisher, B Gollan, S Helaine - Nature Reviews Microbiology, 2017 - nature.com
Many bacteria can infect and persist inside their hosts for long periods of time. This can be
due to immunosuppression of the host, immune evasion by the pathogen and/or ineffective …
due to immunosuppression of the host, immune evasion by the pathogen and/or ineffective …
Antibiotic tolerance facilitates the evolution of resistance
I Levin-Reisman, I Ronin, O Gefen, I Braniss… - Science, 2017 - science.org
Controlled experimental evolution during antibiotic treatment can help to explain the
processes leading to antibiotic resistance in bacteria. Recently, intermittent antibiotic …
processes leading to antibiotic resistance in bacteria. Recently, intermittent antibiotic …
Distinguishing between resistance, tolerance and persistence to antibiotic treatment
Antibiotic tolerance is associated with the failure of antibiotic treatment and the relapse of
many bacterial infections. However, unlike resistance, which is commonly measured using …
many bacterial infections. However, unlike resistance, which is commonly measured using …
Mechanisms of bacterial persistence during stress and antibiotic exposure
A Harms, E Maisonneuve, K Gerdes - Science, 2016 - science.org
BACKGROUND The escalating crisis of multidrug resistance is raising fears of untreatable
infections caused by bacterial “superbugs.” However, many patients already suffer from …
infections caused by bacterial “superbugs.” However, many patients already suffer from …
Intracellular Staphylococcus aureus persisters upon antibiotic exposure
F Peyrusson, H Varet, TK Nguyen, R Legendre… - Nature …, 2020 - nature.com
Bacterial persister cells are phenotypic variants that exhibit a transient non-growing state
and antibiotic tolerance. Here, we provide in vitro evidence of Staphylococcus aureus …
and antibiotic tolerance. Here, we provide in vitro evidence of Staphylococcus aureus …