Using MetaboAnalyst 5.0 for LC–HRMS spectra processing, multi-omics integration and covariate adjustment of global metabolomics data
Liquid chromatography coupled with high-resolution mass spectrometry (LC–HRMS) has
become a workhorse in global metabolomics studies with growing applications across …
become a workhorse in global metabolomics studies with growing applications across …
[HTML][HTML] Non-targeted metabolomics and associations with per-and polyfluoroalkyl substances (PFAS) exposure in humans: A scoping review
Objective To summarize the application of non-targeted metabolomics in epidemiological
studies that assessed metabolite and metabolic pathway alterations associated with per-and …
studies that assessed metabolite and metabolic pathway alterations associated with per-and …
Sampling interstitial fluid from human skin using a microneedle patch
PP Samant, MM Niedzwiecki, N Raviele… - Science translational …, 2020 - science.org
Tissue interstitial fluid (ISF) surrounds cells and is an underutilized source of biomarkers that
complements conventional sources such as blood and urine. However, ISF has received …
complements conventional sources such as blood and urine. However, ISF has received …
Fecal microbiota transplantation promotes reduction of antimicrobial resistance by strain replacement
Multidrug-resistant organism (MDRO) colonization is a fundamental challenge in
antimicrobial resistance. Limited studies have shown that fecal microbiota transplantation …
antimicrobial resistance. Limited studies have shown that fecal microbiota transplantation …
[HTML][HTML] Antibiotics-driven gut microbiome perturbation alters immunity to vaccines in humans
Emerging evidence indicates a central role for the microbiome in immunity. However, causal
evidence in humans is sparse. Here, we administered broad-spectrum antibiotics to healthy …
evidence in humans is sparse. Here, we administered broad-spectrum antibiotics to healthy …
[HTML][HTML] Per-and polyfluoroalkyl substance (PFAS) exposure, maternal metabolomic perturbation, and fetal growth in African American women: A meet-in-the-middle …
Background Prenatal exposures to per-and polyfluoroalkyl substances (PFAS) have been
linked to reduced fetal growth. However, the detailed molecular mechanisms remain largely …
linked to reduced fetal growth. However, the detailed molecular mechanisms remain largely …
One step forward for reducing false positive and false negative compound identifications from mass spectrometry metabolomics data: new algorithms for constructing …
False positive and false negative peaks detected from extracted ion chromatograms (EIC)
are an urgent problem with existing software packages that preprocess untargeted liquid or …
are an urgent problem with existing software packages that preprocess untargeted liquid or …
Metformin rescues Parkinson's disease phenotypes caused by hyperactive mitochondria
Metabolic dysfunction occurs in many age-related neurodegenerative diseases, yet its role
in disease etiology remains poorly understood. We recently discovered a potential causal …
in disease etiology remains poorly understood. We recently discovered a potential causal …
Predicting network activity from high throughput metabolomics
The functional interpretation of high throughput metabolomics by mass spectrometry is
hindered by the identification of metabolites, a tedious and challenging task. We present a …
hindered by the identification of metabolites, a tedious and challenging task. We present a …
Autophagy is essential for effector CD8+ T cell survival and memory formation
The importance of autophagy in the generation of memory CD8+ T cells in vivo is not well
defined. We report here that autophagy was dynamically regulated in virus-specific CD8+ T …
defined. We report here that autophagy was dynamically regulated in virus-specific CD8+ T …