▪ Abstract The matrix metalloproteinases (MMPs) constitute a multigene family of over 25
secreted and cell surface enzymes that process or degrade numerous pericellular …

The metalloproteinases degrade extracellular matrix (ECM) components and activate growth
factors, thereby contributing to physiological events (tissue remodeling in pregnancy, wound …

The proteasome regulates cellular processes as diverse as cell cycle progression and NF-
κB activation. In this study, we show that the potent antitumor natural product epoxomicin …

In mammals, tissue damage is usually repaired by activation of a fibrotic response which
saves the life of the organism, but which can never restore function to the damaged organ. In …

Matrix metalloproteinases (MMPs) are a family of proteolytic enzymes that function to
maintain and remodel tissue architecture. Their substrates represent an astounding variety …

The extracellular matrix is not merely a passive structure. In the past few years, it has
emerged that the matrix is a dynamic action zone that functions to instruct cellular …

Tumor necrosis factor-alpha (TNF-α) is an important mediator during the inflammatory phase
of wound healing. Excessive amounts of pro-inflammatory cytokines such as TNF-α are …

Objectives—Smooth muscle cells (SMCs) produce both matrix metalloproteinase (MMP)-2
and MMP-9, enzymes with similar in vitro matrix degrading abilities. We compared the …

The 92-kDa type IV collagenase (MMP-9) plays a critical role in tissue remodeling. We
undertook a study to determine whether the KiSS-1 gene, previously shown to suppress …

We have studied mechanisms controlling activation of the gelatinase B gene (matrix
metalloproteinase-9) by fibroblast growth factor-2 (FGF-2) during angiogenesis, and the …