Diabetes, a complex multisystem metabolic disorder characterized by hyperglycemia, leads
to complications that reduce quality of life and increase mortality. Diabetes pathophysiology …

Intranasal drug delivery is as a noninvasive and efficient approach extensively utilized for
treating the local, central nervous system, and systemic diseases. Despite numerous …

Exercise has systemic health benefits in people, in part, through improving whole body
insulin sensitivity. The brain is an insulin-sensitive organ that is often underdiscussed …

A decrease in the activity of the insulin signaling system of the brain, due to both central
insulin resistance and insulin deficiency, leads to neurodegeneration and impaired …

Intranasal insulin reduces lesion size and enhances memory capacity in traumatic brain
injury (TBI) models, but the molecular mechanisms behind this neuroprotective action not yet …

Efficacious stem cell-based therapies for traumatic brain injury (TBI) depend on successful
delivery, migration, and engraftment of stem cells to induce neuroprotection. L-myc …

Background Postoperative cognitive impairment are common neural complications in older
surgical patients and exacerbate the burden of medical care on families and society …

Background Aberrant brain insulin signaling has been posited to lie at the crossroads of
several metabolic and cognitive disorders. Intranasal insulin (INI) is a non-invasive …

Aims Insulin action in the brain influences cognitive processes, peripheral metabolism and
eating behaviour. However, the influence of age and peripheral insulin sensitivity on brain …

Despite the availability of combined antiretroviral therapy (cART), which reduces the HIV
replication in chronically HIV-infected patients, HIV associated neurocognitive disorders …