Unraveling plant natural chemical diversity for drug discovery purposes
E Lautié, O Russo, P Ducrot, JA Boutin - Frontiers in pharmacology, 2020 - frontiersin.org
The screening and testing of extracts against a variety of pharmacological targets in order to
benefit from the immense natural chemical diversity is a concern in many laboratories …
benefit from the immense natural chemical diversity is a concern in many laboratories …
Advanced methods for natural products discovery: bioactivity screening, dereplication, metabolomics profiling, genomic sequencing, databases and informatic tools …
Natural Products (NP) are essential for the discovery of novel drugs and products for
numerous biotechnological applications. The NP discovery process is expensive and time …
numerous biotechnological applications. The NP discovery process is expensive and time …
Accelerating metabolite identification in natural product research: toward an ideal combination of liquid chromatography–high-resolution tandem mass spectrometry …
Natural product research aims to characterize specialized metabolites from various living
organisms and assess their biological properties from either a chemical ecology or drug …
organisms and assess their biological properties from either a chemical ecology or drug …
Innovative omics-based approaches for prioritisation and targeted isolation of natural products–new strategies for drug discovery
Covering: 2013 to 2019 The exploration of the chemical diversity of extracts from various
biological sources has led to major drug discoveries. Over the past two decades, despite the …
biological sources has led to major drug discoveries. Over the past two decades, despite the …
Novel bioactive natural products from bacteria via bioprospecting, genome mining and metabolic engineering
ON Sekurova, O Schneider… - Microbial biotechnology, 2019 - Wiley Online Library
For over seven decades, bacteria served as a valuable source of bioactive natural products
some of which were eventually developed into drugs to treat infections, cancer and immune …
some of which were eventually developed into drugs to treat infections, cancer and immune …
Current status and contemporary approaches to the discovery of antitumor agents from higher plants
G Agarwal, PJB Carcache, EM Addo… - Biotechnology advances, 2020 - Elsevier
Higher plant constituents have afforded clinically available anticancer drugs. These include
both chemically unmodified small molecules and their synthetic derivatives currently used or …
both chemically unmodified small molecules and their synthetic derivatives currently used or …
The integration of LC‐MS and NMR for the analysis of low molecular weight trace analytes in complex matrices
RM Gathungu, R Kautz, BS Kristal… - Mass spectrometry …, 2020 - Wiley Online Library
This review discusses the integration of liquid chromatography (LC), mass spectrometry
(MS), and nuclear magnetic resonance (NMR) in the comprehensive analysis of small …
(MS), and nuclear magnetic resonance (NMR) in the comprehensive analysis of small …
Marine-derived anticancer agents: Clinical benefits, innovative mechanisms, and new targets
RB Pereira, NM Evdokimov, F Lefranc, P Valentão… - Marine drugs, 2019 - mdpi.com
The role of the marine environment in the development of anticancer drugs has been widely
reviewed, particularly in recent years. However, the innovation in terms of clinical benefits …
reviewed, particularly in recent years. However, the innovation in terms of clinical benefits …
Natural polysaccharides as preventive and therapeutic horizon for neurodegenerative diseases
Neurodegenerative diseases are a serious and widespread global public health burden
amongst aging populations. The total estimated worldwide global cost of dementia was US 818billionin2015andhasbeenprojectedtoris …
amongst aging populations. The total estimated worldwide global cost of dementia was US 818billionin2015andhasbeenprojectedtoris …
[PDF][PDF] Medicinal plants and their secondary metabolites—State of the art and trends in breeding, analytics and use in feed supplementation—With special focus on …
B Faehnrich, C Franz, P Nemaz, HP Kaul - J. Appl. Bot. Food Qual, 2021 - researchgate.net
Plants in ecology interact with their biotic and abiotic environment. Means of interactions,
and thereby crucial for the survival of the species, are secondary plant metabolites …
and thereby crucial for the survival of the species, are secondary plant metabolites …