Cardiovascular diseases (CVDs) are the major causes of death in the western world. The
incidence of cardiovascular disease as well as the rate of cardiovascular mortality and …

While natural and synthetic N-nucleosides are vulnerable to enzymatic and acid-catalyzed
hydrolysis of the nucleosidic bond, their C-analogues are much more stable. Several C …

A variety of nucleoside analogues have now been discovered which expand the antiviral
and anticancer spectrum and/or modify the pharmacological and/or pharmacokinetic …

For many years, the purine salvage pathway of parasitic protozoa has been regarded as an
attractive chemotherapeutic target. Parasitic protozoa lack de novo synthesis and rely …

Dinitropyrazoles Page 1 Russian Chemical Reviews Dinitropyrazoles To cite this article: AA
Zaitsev et al 2009 Russ. Chem. Rev. 78 589 View the article online for updates and …

Purine nucleoside phosphorylases (PNPs) catalyze nucleophilic displacement reactions by
migration of the cationic ribooxacarbenium carbon between the fixed purine and phosphate …

The aza-C-nucleosides, Immucillin-H and Immucillin-G, are transition state analogue
inhibitors of purine nucleoside phosphorylase, a therapeutic target for the control of T-cell …

C-Analogues of the canonical N-nucleosides have considerable importance in medicinal
chemistry and are promising building blocks of xenobiotic nucleic acids (XNA) in synthetic …

This Review describes the existing synthetic approaches for the solid-phase synthesis (SPS)
of differently substituted and fused pyrimidine derivatives. These synthetic strategies are …

An enantioselective vinylogous amination of 5-alkyl-4-nitroisoxazoles is reported. With a
novel chiral dipeptide-based urea–amide–guanidinium as the phase-transfer catalyst, the …