Arynes are among the most active organic intermediates and have found numerous
applications in expeditious preparation of substituted arenes. In the past 20 years, chemists …

Metal‐catalyzed cross coupling reactions are efficient synthetic methods and developing
continuously for the synthesis of diverse range of heterocycles, found in wide range of …

The pyridine heterocycle continues to play a vital role in the development of human
medicines. More than 100 currently marketed drugs contain this privileged unit, which …

Molecular editing promises to facilitate the rapid diversification of complex molecular
architectures by rapidly and conveniently altering core frameworks. This approach has the …

The chemistry of strained cyclic alkynes has undergone a renaissance over the past two
decades. However, a related species, strained cyclic allenes, especially heterocyclic …

The aryl O-carbamate (ArOAm) group is among the strongest of the directed metalation
groups (DMGs) in directed ortho metalation (D o M) chemistry, especially in the form Ar …

In the context of naturally occurring nitrogen heterocycles, nicotine is a chiral alkaloid
present in tobacco plants, which can target and stimulate nicotinic acetylcholine receptors …

Several o-(trimethylsilyl) aryl imidazolylsulfonates were synthesized in a simple process and
successfully applied in cycloadditions involving benzyne intermediates. The precursor offers …

The use of palladium catalysts in fused ring synthesis has been increasingly noteworthy in
recent years in organic synthesis. It has a lot of potential compared to other transition metal …

Silyl triflate precursors to benzyne and related intermediates have emerged as valuable
synthetic building blocks. However, data addressing the safety of employing these silyl …