Analysis of intestinal epithelial cell responses to Cryptosporidium highlights the temporal effects of IFN-γ on parasite restriction

RD Pardy, KA Walzer, BA Wallbank, JH Byerly… - Plos …, 2024 - journals.plos.org
The production of IFN-γ is crucial for control of multiple enteric infections, but its impact on
intestinal epithelial cells (IEC) is not well understood. Cryptosporidium parasites exclusively …

Cryptosporidium impacts epithelial turnover and is resistant to induced death of the host cell

BA Wallbank, RD Pardy, IE Brodsky, CA Hunter… - Mbio, 2024 - journals.asm.org
Infection with the apicomplexan parasite Cryptosporidium is a leading cause of diarrheal
disease. Cryptosporidiosis is of particular importance in infants and shows a strong …

Intestinal cDC1s provide cues required for CD4+ T cell–mediated resistance to Cryptosporidium

IS Cohn, BA Wallbank, BE Haskins, KM O'Dea… - Journal of Experimental …, 2024 - rupress.org
Cryptosporidium is an enteric pathogen and a prominent cause of diarrheal disease
worldwide. Control of Cryptosporidium requires CD4+ T cells, but how protective CD4+ T …

Mechanisms of CD4+ T Cell-Dependent Resistance Against Cryptosporidium

IS Cohn - 2024 - search.proquest.com
Cryptosporidium species can cause sporadic waterborne diarrhea outbreaks but infections
can be a significant cause of morbidity and mortality in malnourished children and …