Calcium (Ca2+) is a universal regulator of various cellular functions. In cardiomyocytes,
Ca2+ is the central element of excitation–contraction coupling, but also impacts diverse …

The nucleus, a genome-containing organelle eponymous of eukaryotes, is enclosed by a
double membrane continuous with the endoplasmic reticulum. The nuclear pore complex …

The p38 mitogen-activated protein kinase (p38MAPK, termed here p38) cascade is a central
signaling pathway that transmits stress and other signals to various intracellular targets in …

Nuclear pores are essential for nuclear-cytoplasmic transport. Whether and how cells
change nuclear pores to alter nuclear transport and cellular function is unknown. Here, we …

This minireview discusses the evidence that the inhibition of p38 mitogen-activated protein
kinases (p38 MAPKs) maybe of therapeutic value in heart failure. Most previous …

When a therapeutic molecule is administered into a biological system, it faces numerous
barriers on its way to the target site. While a portion of the administered dose can overcome …

The nucleus of a cardiomyocyte has been increasingly recognized as a morphologically
distinct and partially independent calcium (Ca2+) signaling microdomain, with its own Ca2+ …

The eukaryotic cell nucleus houses an organism's genome and is the location within the cell
where all signaling induced and development-driven gene expression programs are …

Alteration of the nuclear Ca2+ transient is an early event in cardiac remodeling. Regulation
of the nuclear Ca2+ transient is partly independent of the cytosolic Ca2+ transient in …

The subcellular compartmentalisation of eukaryotic cells requires selective exchange
between the cytoplasm and the nucleus. Intact nucleocytoplasmic transport is vital for normal …