The structure of the brain is constantly changing from birth throughout the lifetime, meaning
that normal aging, free from dementia, is associated with structural brain changes. This …

Brain-derived neurotrophic factor (BDNF) has a primary role in neuronal development,
differentiation and plasticity in both the developing and adult brain. A single-nucleotide …

Hippocampal volume shrinks in late adulthood, but the neuromolecular factors that trigger
hippocampal decay in aging humans remains a matter of speculation. In rodents, brain …

Background Brain-derived neurotrophic factor is implicated in the pathophysiology of major
depressive disorder and suicide. Both are partly caused by early life adversity, which …

Schizophrenia is believed to arise from complex gene–environment interactions. Brain-
derived neurotrophic factor (BDNF) is involved in neuronal development, differentiation and …

Brain-derived neurotrophic factor (BDNF) is the most widely distributed neurotrophin in the
CNS, where it plays several pivotal roles in synaptic plasticity and neuronal survival. As a …

BackgroundThe role of the brain-derived neurotrophic factor (BDNF) in the pathogenesis of
affective disorders such as depression has been controversial. Mounting evidence comes …

Context The brain-derived neurotrophic factor (BDNF) Val66Met (rs6265) polymorphism
may predict the risk of Alzheimer disease (AD). However, genetic association studies of …

Brain derived neurotrophic factor (BDNF) is a critical component of the molecular
mechanism of memory formation. Variation in the BDNF gene, particularly the rs6265 …

Aging of the human brain is associated with “normal” functional, structural, and molecular
changes that underlie alterations in cognition, memory, mood and motor function, amongst …