Treatment options for motor and non-motor symptoms of Parkinson's disease

FC Church - Biomolecules, 2021 - mdpi.com
Parkinson's disease (PD) usually presents in older adults and typically has both motor and
non-motor dysfunctions. PD is a progressive neurodegenerative disorder resulting from …

Current understanding of the molecular mechanisms in Parkinson's disease: Targets for potential treatments

P Maiti, J Manna, GL Dunbar - Translational neurodegeneration, 2017 - Springer
Gradual degeneration and loss of dopaminergic neurons in the substantia nigra, pars
compacta and subsequent reduction of dopamine levels in striatum are associated with …

Aerobic exercise alters brain function and structure in Parkinson's disease: a randomized controlled trial

ME Johansson, IGM Cameron… - Annals of …, 2022 - Wiley Online Library
Objective Randomized clinical trials have shown that aerobic exercise attenuates motor
symptom progression in Parkinson's disease, but the underlying neural mechanisms are …

Effect of high-intensity treadmill exercise on motor symptoms in patients with de novo Parkinson disease: a phase 2 randomized clinical trial

M Schenkman, CG Moore, WM Kohrt, DA Hall… - JAMA …, 2018 - jamanetwork.com
Importance Parkinson disease is a progressive neurologic disorder. Limited evidence
suggests endurance exercise modifies disease severity, particularly high-intensity exercise …

Virtual reality in research and rehabilitation of gait and balance in Parkinson disease

CG Canning, NE Allen, E Nackaerts, SS Paul… - Nature Reviews …, 2020 - nature.com
Virtual reality (VR) technology has emerged as a promising tool for studying and
rehabilitating gait and balance impairments in people with Parkinson disease (PD) as it …

[HTML][HTML] Virtual reality rehabilitation versus conventional physical therapy for improving balance and gait in Parkinson's disease patients: a randomized controlled trial

H Feng, C Li, J Liu, L Wang, J Ma, G Li… - … medical journal of …, 2019 - ncbi.nlm.nih.gov
Virtual Reality Rehabilitation Versus Conventional Physical Therapy for Improving Balance
and Gait in Parkinson’s Disease Patients: A Randomized Controlled Trial - PMC Back to Top …

Voluntary exercise boosts striatal dopamine release: evidence for the necessary and sufficient role of BDNF

G Bastioli, JC Arnold, M Mancini, AC Mar… - Journal of …, 2022 - Soc Neuroscience
Physical exercise improves motor performance in individuals with Parkinson9s disease and
elevates mood in those with depression. Although underlying factors have not been …

The protective role of exercise against age-related neurodegeneration

A Sujkowski, L Hong, RJ Wessells, SV Todi - Ageing Research Reviews, 2022 - Elsevier
Endurance exercise is a widely accessible, low-cost intervention with a variety of benefits to
multiple organ systems. Exercise improves multiple indices of physical performance and …

Rehabilitation for Parkinson's disease: current outlook and future challenges

G Abbruzzese, R Marchese, L Avanzino… - Parkinsonism & related …, 2016 - Elsevier
Rehabilitation is considered as an adjuvant to pharmacological and surgical treatments for
Parkinson's disease (PD) to maximize functional ability and minimize secondary …

Effectiveness of home-based and remotely supervised aerobic exercise in Parkinson's disease: a double-blind, randomised controlled trial

NM Van der Kolk, NM de Vries, RPC Kessels… - The Lancet …, 2019 - thelancet.com
Background High-intensity aerobic exercise might attenuate the symptoms of Parkinson's
disease, but high-quality evidence is scarce. Moreover, long-term adherence remains …