Microwave-assisted synthesis of bioactive heterocycles: An overview
Microwave-assisted synthesis of numerous bioactive scaffolds has gained much attention of
late in organic chemistry. Most of the heterocyclic rings can be synthesized using the …
late in organic chemistry. Most of the heterocyclic rings can be synthesized using the …
Recent advances on synthesis and biological activities of C-17 aza-heterocycle derived steroids
H Huo, G Li, B Shi, J Li - Bioorganic & Medicinal Chemistry, 2022 - Elsevier
Steroids modification for improving their biological activities is one of the most efficient and
fruitful methods to develop novel medicines. Steroids with aza-heterocycles attaching to the …
fruitful methods to develop novel medicines. Steroids with aza-heterocycles attaching to the …
Core–shell nanoparticles suppress metastasis and modify the tumour-supportive activity of cancer-associated fibroblasts
Background Although accumulating evidence suggests that the crosstalk between malignant
cells and cancer-associated fibroblasts (CAFs) actively contributes to tumour growth and …
cells and cancer-associated fibroblasts (CAFs) actively contributes to tumour growth and …
Semi-synthesis and cytotoxicity evaluation of pyrimidine, thiazole, and indole analogues of argentatins A–C from guayule (Parthenium argentatum) resin
C Madasu, YM Xu, EMK Wijeratne, MX Liu… - Medicinal Chemistry …, 2022 - Springer
Abstract Argentatins A–C (1–3), the major cycloartane-type triterpenoids of guayule resin, a
byproduct of commercial rubber production, were converted into their pyrimidine (7–12) …
byproduct of commercial rubber production, were converted into their pyrimidine (7–12) …
Functionalized mesoporous silica nanoparticles for drug-delivery to multidrug-resistant cancer cells
Background Multidrug resistance is a common reason behind the failure of chemotherapy.
Even if the therapy is effective, serious adverse effects might develop due to the low …
Even if the therapy is effective, serious adverse effects might develop due to the low …
Formation of nitrogen-containing six-membered heterocycles on steroidal ring system: A review
K Sharma, H Kumar - Steroids, 2023 - Elsevier
Steroidal heterocyclic compounds constitute interesting and promising scaffolds for drug
discovery as they have displayed diverse chemical reactivity and several types of biological …
discovery as they have displayed diverse chemical reactivity and several types of biological …
Heterocyclic steroids: Efficient routes for annulation of pentacyclic steroidal pyrimidines
Steroids are components of cell membranes, signaling molecules and are a type of
secondary metabolites as a result of their high impact of biological significance. The present …
secondary metabolites as a result of their high impact of biological significance. The present …
[HTML][HTML] Synthesis of dihydrotestosterone derivatives modified in the A-ring with (hetero) arylidene, pyrazolo [1, 5-a] pyrimidine and triazolo [1, 5-a] pyrimidine moieties …
One of the main directions of steroid research is the preparation of modified derivatives in
which, in addition to changes in physicochemical properties, receptor binding is significantly …
which, in addition to changes in physicochemical properties, receptor binding is significantly …
Advances in the synthesis of heterocycles bearing an endocyclic urea moiety
AV Smolobochkin, AS Gazizov… - Russian Chemical …, 2021 - iopscience.iop.org
The review systematizes and summarizes data on the synthesis of structurally diverse cyclic
ureas published over the last 10 years. Saturated and unsaturated monocyclic ureas, as well …
ureas published over the last 10 years. Saturated and unsaturated monocyclic ureas, as well …
Steroid diversification by multicomponent reactions
L Reguera, CI Attorresi, JA Ramírez… - Beilstein Journal of …, 2019 - beilstein-journals.org
Reports on structural diversification of steroids by means of multicomponent reactions
(MCRs) have significantly increased over the last decade. This review covers the most …
(MCRs) have significantly increased over the last decade. This review covers the most …