The advent of iPSCs has brought about a significant transformation in stem cell research,
opening up promising avenues for advancing cancer treatment. The formation of cancer is a …

Genome editing using the clustered regularly interspaced short palindromic repeats
(CRISPR) and CRISPR-associated protein (Cas) gene-editing system (CRISPR-Cas) is a …

Accurate modeling of the heart electrophysiology to predict arrhythmia susceptibility remains
a challenge. Current electrophysiological analyses are hypothesis-driven models drawing …

Precise genome editing in human pluripotent stem cells (hPSCs) has potential applications
in isogenic disease modeling and ex vivo stem cell therapy, necessitating diverse genome …

Induced pluripotent stem cell (iPSC) and gene editing technologies have revolutionized the
field of in vitro disease modeling, granting us access to disease-pertinent human cells of the …

CRISPR/Cas gene drives can bias transgene inheritance through different mechanisms.
Homing drives are designed to replace a wild-type allele with a copy of a drive element on …

CRISPR/Cas9 based gene editing typically functions by creating a DNA double-strand break
(DSB) at the intended target locus in a cell. Recent reports showed the occurrence of …

Inherited retinal dystrophies comprise a broad group of genetic eye diseases without
effective treatment. Among them, Stargardt disease is the second most prevalent pathology …

Owing to the advances in genome editing technologies, research on human pluripotent stem
cells (hPSCs) have recently undergone breakthroughs that enable precise alteration of …

CRISPR nucleases can introduce double-stranded DNA breaks in genomes at positions
specified by guide RNAs. When repaired by the cell, this may result in the introduction of …