The utility of the rodent synergist ablation model in identifying molecular and cellular mechanisms of skeletal muscle hypertrophy

BI Burke, A Ismaeel… - American Journal of …, 2024 - journals.physiology.org
Skeletal muscle exhibits remarkable plasticity to adapt to stimuli such as mechanical
loading. The mechanisms that regulate skeletal muscle hypertrophy due to mechanical …

The utility—and limitations—of the rodent synergist ablation model in examining mechanisms of skeletal muscle hypertrophy

MD Roberts, TA Hornberger… - American Journal of …, 2024 - journals.physiology.org
In this issue, Burke et al. discuss the utility of the rodent synergist ablation (SA) model for
examining mechanisms associated with skeletal muscle hypertrophy. In this invited …

Methylome–proteome integration after late‐life voluntary exercise training reveals regulation and target information for improved skeletal muscle health

TL Chambers, A Dimet‐Wiley, AR Keeble… - The Journal of …, 2024 - Wiley Online Library
Exercise is a potent stimulus for combatting skeletal muscle ageing. To study the effects of
exercise on muscle in a preclinical setting, we developed a combined endurance …

Skeletal muscle hypertrophy: cell growth is cell growth

BI Burke, A Ismaeel, F von Walden… - … of Physiology-Cell …, 2024 - journals.physiology.org
Roberts et al. have provided an insightful counterpoint to our review article on the utility of
the synergist ablation model. The purpose of this review is to provide some further dialogue …

[HTML][HTML] The 24-Hour Time Course of Integrated Molecular Responses to Resistance Exercise in Human Skeletal Muscle Implicates MYC as a Hypertrophic Regulator …

S Edman, RG Jones III, PR Jannig… - bioRxiv, 2024 - ncbi.nlm.nih.gov
Molecular control of recovery after exercise in muscle is temporally dynamic. A time course
of biopsies around resistance exercise (RE) combined with-omics is necessary to better …

[HTML][HTML] Landmark Review: The utility of the rodent synergist ablation model in identifying molecular and cellular mechanisms of skeletal muscle hypertrophy

BI Burke, A Ismaeel, JJ McCarthy - American Journal of Physiology …, 2024 - ncbi.nlm.nih.gov
Skeletal muscle exhibits remarkable plasticity to adapt to stimuli such as mechanical
loading. The mechanisms that regulate skeletal muscle hypertrophy due to mechanical …

The rRNA epitranscriptome and myonuclear SNORD landscape in skeletal muscle fibers contributes to ribosome heterogeneity and is altered by a hypertrophic …

M Cui, P Jannig, M Halladjian… - … of Physiology-Cell …, 2024 - journals.physiology.org
In cell biology, ribosomal RNA (rRNA) 2′ O-methyl (2′-O-Me) is the most prevalent
posttranscriptional chemical modification contributing to ribosome heterogeneity. The …

[HTML][HTML] microRNA-1 Regulates Metabolic Flexibility in Skeletal Muscle via Pyruvate Metabolism

A Ismaeel, BD Peck, MLM Montgomery, BI Burke… - bioRxiv, 2024 - ncbi.nlm.nih.gov
Abstract MicroRNA-1 (miR-1) is the most abundant miRNA in adult skeletal muscle. To
determine the function of miR-1 in adult skeletal muscle, we generated an inducible, skeletal …

The risks and rewards of the synergist ablation model in skeletal muscle biology research

AL Syroid, TJ Hawke - American Journal of Physiology-Cell …, 2024 - journals.physiology.org
The use of the synergist ablation model to induce muscle hypertrophy has a long and 27
storied history in skeletal muscle research. First reported in the American Journal of 28 …