The first matrix metalloproteinase (MMP) was discovered in 1962 from the tail of a tadpole by
its ability to degrade collagen. As their name suggests, matrix metalloproteinases are …

Viral myocarditis remains a prominent infectious-inflammatory disease for patients
throughout the lifespan. The condition presents several challenges including varied modes …

Viral myocarditis has been identified as a major cause of dilated cardiomyopathy (DCM) that
can lead to heart failure. Historically, Coxsackieviruses and adenoviruses have been …

Evidence from both experimental and clinical trials indicates that inflammatory mediators are
of importance in the pathogenesis of chronic heart failure (HF) contributing to cardiac …

The role of the host extracellular matrix (ECM) in infection tends to be neglected. However,
the complex interactions between invading pathogens, host tissues and immune cells occur …

Viruses such as coxsackievirus B3 (CVB3) are entirely host cell-dependent parasites.
Indeed, they must cleverly exploit various compartments of host cells to complete their life …

Abstract Interferon-α (IFN-α) is essential for antiviral immunity, but in the absence of matrix
metalloproteinase-12 (MMP-12) or IκBα (encoded by NFKBIA) we show that IFN-α is …

Over the past three decades, numerous studies have shown a strong connection between
matrix metalloproteinase 9 (MMP-9) levels and myocardial infarction (MI) mortality and left …

OBJECTIVES: We studied fibrosis, collagen metabolism, MMPs/TIMPs and cytokine
expression in various forms of human heart failure (HF) by quantitative immunofluorescent …

Matrix metalloproteinases (MMPs) have been studied in the context of cancer due to their
ability to increase cell invasion, and were initially thought to facilitate metastasis solely …