Chronic pain exerts an enormous personal and economic burden, affecting more than 30%
of people worldwide according to some studies. Unlike acute pain, which carries survival …

Chronic pain is a leading cause of disability globally and associated with enormous health-
care costs. The discrepancy between the extent of tissue damage and the magnitude of …

Objective To assess the effectiveness and safety of different preparations and doses of non-
steroidal anti-inflammatory drugs (NSAIDs), opioids, and paracetamol for knee and hip …

Objective To determine the benefits and harms of medical cannabis and cannabinoids for
chronic pain. Design Systematic review and meta-analysis. Data sources MEDLINE …

Objective To develop an evidence‐based guideline for the comprehensive management of
osteoarthritis (OA) as a collaboration between the American College of Rheumatology …

The adenosine A1 receptor (A1R) is a promising therapeutic target for non-opioid analgesic
agents to treat neuropathic pain,. However, development of analgesic orthosteric A1R …

Background: The management of acute and chronic pain for individuals living with sickle cell
disease (SCD) is a clinical challenge. This reflects the paucity of clinical SCD pain research …

Clinical question What is the role of medical cannabis or cannabinoids for people living with
chronic pain due to cancer or non-cancer causes? Current practice Chronic pain is common …

Background A significant number of patients use opioids prior to total joint arthroplasty (TJA)
in North America and there is growing concern that preoperative opioid use negatively …

Introduction: Given our improved understanding of the role of central sensitization (CS) in
many patients with chronic pain, it seems rational to account for CS during treatment. Areas …