Ca2+-release channels are giant membrane proteins that control the release of Ca2+ from
the endoplasmic and sarcoplasmic reticulum. The two members, ryanodine receptors …

Cellular Ca 2+ homeostasis is maintained through the integrated and coordinated function
of Ca 2+ transport molecules, Ca 2+ buffers and sensors. These molecules are associated …

Abstract Uncoupling protein 1 (UCP1) plays a central role in nonshivering thermogenesis in
brown fat; however, its role in beige fat remains unclear. Here we report a robust UCP1 …

Neuromuscular disorders comprise a diverse group of human inborn diseases that arise
from defects in the structure and/or function of the muscle tissue—encompassing the muscle …

The congenital myopathies are a group of early-onset, non-dystrophic neuromuscular
conditions with characteristic muscle biopsy findings, variable severity and a stable or slowly …

Ion channels are membrane proteins that act as gated pathways for the movement of ions
across cell membranes. They play essential roles in the physiology of all cells. In recent …

Ryanodine receptors (RyRs) are huge ion channels that are responsible for the release of
Ca 2+ from the sarco/endoplasmic reticulum. RyRs form homotetramers with a mushroom …

Ryanodine receptors (RyRs) are a distinct class of ligand-gated calcium channels
controlling the release of calcium from intracellular stores. They are located on the …

By the introduction of technological advancement in methods of structural analysis,
electronics, and recombinant DNA techniques, research in physiology has become …

The RYR1 gene encodes the skeletal muscle isoform ryanodine receptor and is
fundamental to the process of excitation–contraction coupling and skeletal muscle calcium …