T cells are crucial for immune functions to maintain health and prevent disease. T cell
development occurs in a stepwise process in the thymus and mainly generates CD4+ and …

Melanoma is the most lethal skin cancer that originates from the malignant transformation of
melanocytes. Although melanoma has long been regarded as a cancerous malignancy with …

Tumor infiltrating leukocytes (TILs) are an integral component of the tumor microenvironment
and have been found to correlate with prognosis and response to therapy. Methods to …

We concurrently examine the whole genome, transcriptome, methylome, and immune cell
infiltrates in baseline tumors from 77 patients with advanced cutaneous melanoma treated …

We describe the landscape of genomic alterations in cutaneous melanomas through DNA,
RNA, and protein-based analysis of 333 primary and/or metastatic melanomas from 331 …

Numerous analyses of large patient cohorts identified specific patterns of immune activation
associated with patient survival. We established these as the immune contexture …

Purpose: Multiple BRAF inhibitor resistance mechanisms have been described, however,
their relative frequency, clinical correlates, and effect on subsequent therapy have not been …

One-third of BRAF-mutant metastatic melanoma patients treated with combined BRAF and
MEK inhibition progress within 6 months. Treatment options for these patients remain …

The immune composition of the tumor microenvironment regulates processes including
angiogenesis, metastasis, and the response to drugs or immunotherapy. To facilitate the …

Background Recently, TERT promoter mutations were identified at high frequencies in
cutaneous melanoma tumor samples and cell lines. The mutations were found to have a UV …