The bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase (MTHFD2) is a
mitochondrial one-carbon folate metabolic enzyme whose role in cancer was not known …

Background A significant proportion of colorectal cancer (CRC) patients suffer from early
recurrence and progression after surgical treatment. Although the gut microbiota is …

Cytidine triphosphate synthase (CTPS), which comprises an ammonia ligase domain and a
glutamine amidotransferase domain, catalyzes the final step of de novo CTP biosynthesis …

Membrane trafficking is a core cellular process that supports diversification of cell shapes
and behaviors relevant to morphogenesis during development and in adult organisms …

Phosphoribosyl pyrophosphate (PRPP) is a key intermediate in the biosynthesis of purine
and pyrimidine nucleotides, histidine, tryptophan, and cofactors NAD and NADP. Abnormal …

The cytoophidium is a unique type of membraneless compartment comprising of filamentous
protein polymers. Inosine monophosphate dehydrogenase (IMPDH) catalyzes the rate …

Abstract Methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) is a bifunctional enzyme
located in the mitochondria. It has been reported to be overexpressed in several …

Many different enzymes in intermediate metabolism dynamically assemble filamentous
polymers in cells, often in response to changes in physiological conditions. Most of the …

Dear Editor, Intracellular compartmentation of biological processes is fundamental for a cell
to function. One method is to form membrane-bound organelles, such as the mitochondria …

Asparagine synthetase (ASNS) and CTP synthase (CTPS) are two metabolic enzymes
crucial for glutamine homeostasis. A genome-wide screening in Saccharomyces cerevisiae …