Megakaryocytes are hematopoietic cells, which are responsible for the production of blood
platelets. The traditional view of megakaryopoiesis describes the cellular journey from …

Defining how organ size is regulated, a process controlled not only by the number of cells
but also by the size of the cells, is a frontier in developmental biology. Large cells are …

Polyploid cells, which contain multiple copies of the typically diploid genome, are
widespread in plants and animals. Polyploidization can be developmentally programmed or …

Highlights•MK endomitosis is associated with both a defect in cytokinesis and
karyokinesis.•A myosin II accumulation defect at the furrow induces the cytokinesis …

The hallmark of embryonic development is regulation–the tendency for cells to find their way
into organized and 'well behaved'structures–whereas cancer is characterized by …

Polyploidy is defined as a cell with three or more whole genome sets and enables cell
growth across the kingdoms of life. Studies in model organisms have revealed that polyploid …

How platelets are produced by megakaryocytes in vivo remains controversial despite more
than a century of investigation. Megakaryocytes readily produce proplatelet structures in …

Therapeutic resistance represents a major cause of death for most lethal cancers. However,
the underlying mechanisms of such resistance have remained unclear. The polyploid cells …

One of the important functions of regulated cell death is to prevent cells from inappropriately
acquiring extra copies of their genome, a state known as polyploidy. Apoptosis is the primary …

Polyploidy is defined as an increase in genome DNA content. Throughout the plant and
animal kingdoms specific cell types become polyploid as part of their differentiation …