[HTML][HTML] Precision medicine advances in idiopathic pulmonary fibrosis
T Karampitsakos, BM Juan-Guardela, A Tzouvelekis… - …, 2023 - thelancet.com
Idiopathic pulmonary fibrosis (IPF) is a highly heterogeneous, unpredictable and ultimately
lethal chronic lung disease. Over the last decade, two anti-fibrotic agents have been shown …
lethal chronic lung disease. Over the last decade, two anti-fibrotic agents have been shown …
Genetics of chronic respiratory disease
Chronic respiratory diseases, such as chronic obstructive pulmonary disease (COPD),
asthma and interstitial lung diseases are frequently occurring disorders with a polygenic …
asthma and interstitial lung diseases are frequently occurring disorders with a polygenic …
[HTML][HTML] Global Biobank Meta-analysis Initiative: Powering genetic discovery across human disease
Biobanks facilitate genome-wide association studies (GWASs), which have mapped
genomic loci across a range of human diseases and traits. However, most biobanks are …
genomic loci across a range of human diseases and traits. However, most biobanks are …
[HTML][HTML] Meta-analysis fine-mapping is often miscalibrated at single-variant resolution
Meta-analysis is pervasively used to combine multiple genome-wide association studies
(GWASs). Fine-mapping of meta-analysis studies is typically performed as in a single-cohort …
(GWASs). Fine-mapping of meta-analysis studies is typically performed as in a single-cohort …
[HTML][HTML] Global Biobank analyses provide lessons for developing polygenic risk scores across diverse cohorts
Polygenic risk scores (PRSs) have been widely explored in precision medicine. However,
few studies have thoroughly investigated their best practices in global populations across …
few studies have thoroughly investigated their best practices in global populations across …
[HTML][HTML] Genotyping and population characteristics of the China Kadoorie Biobank
RG Walters, IY Millwood, K Lin, DS Valle, P McDonnell… - Cell Genomics, 2023 - cell.com
Summary The China Kadoorie Biobank (CKB) is a population-based prospective cohort of>
512,000 adults recruited from 2004 to 2008 from 10 geographically diverse regions across …
512,000 adults recruited from 2004 to 2008 from 10 geographically diverse regions across …
[HTML][HTML] Proteome-wide Mendelian randomization in global biobank meta-analysis reveals multi-ancestry drug targets for common diseases
Proteome-wide Mendelian randomization (MR) shows value in prioritizing drug targets in
Europeans but with limited evidence in other ancestries. Here, we present a multi-ancestry …
Europeans but with limited evidence in other ancestries. Here, we present a multi-ancestry …
[HTML][HTML] An ensemble penalized regression method for multi-ancestry polygenic risk prediction
Great efforts are being made to develop advanced polygenic risk scores (PRS) to improve
the prediction of complex traits and diseases. However, most existing PRS are primarily …
the prediction of complex traits and diseases. However, most existing PRS are primarily …
Prioritization of genes for translation: A computational approach
SC da Silva Rosa, A Barzegar Behrooz… - Expert Review of …, 2024 - Taylor & Francis
Introduction Gene identification for genetic diseases is critical for the development of new
diagnostic approaches and personalized treatment options. Prioritization of gene translation …
diagnostic approaches and personalized treatment options. Prioritization of gene translation …
Recent advances in the genetics of idiopathic pulmonary fibrosis
P Spagnolo, JS Lee - Current Opinion in Pulmonary Medicine, 2023 - journals.lww.com
Recent advances in the genetics of idiopathic pulmonary fibr... : Current Opinion in Pulmonary
Medicine Recent advances in the genetics of idiopathic pulmonary fibrosis : Current Opinion …
Medicine Recent advances in the genetics of idiopathic pulmonary fibrosis : Current Opinion …