Hydrogel is a type of versatile platform with various biomedical applications after rational
structure and functional design that leverages on material engineering to modulate its …

In 1892, JL Wolff proposed that bone could respond to mechanical and biophysical stimuli
as a dynamic organ. This theory presents a unique opportunity for investigations on bone …

Mechanical forces are fundamental regulators of cell behaviors. However, molecular
regulation of mechanotransduction remain poorly understood. Here, we identified the …

Embryogenic developmental processes involve a tightly controlled regulation between
mechanical forces and biochemical cues such as growth factors, matrix proteins, and …

The penultimate effectors of the Hippo signaling pathways YAP and TAZ, are transcriptional
co-activator proteins that play key roles in many diverse biological processes, ranging from …

Summary The Hippo/Yes-associated protein (YAP) pathway has pivotal roles in innate
immune responses against pathogens in macrophages. However, the role of YAP in …

The biomechanical environment plays a dominant role in fracture healing, and Piezo1 is
regarded as a major mechanosensor in bone homeostasis. However, the role of Piezo1 in …

The Wnt signalling pathway is one of the central signalling pathways in bone development,
homeostasis and regulation of bone mineral density. It consists of numerous Wnt ligands …

Runt-related transcription factor 1 (Runx1) plays a key role in cartilage formation, but its
function in articular cartilage formation is unclear. We generated non-inducible and …

Osteogenic glue that reproduces the natural bone composition represents the final frontier of
orthopedic adhesives with the potential to revolutionize surgical strategies against …