Current hydrogel advances in physicochemical and biological response-driven biomedical application diversity
H Cao, L Duan, Y Zhang, J Cao, K Zhang - Signal transduction and …, 2021 - nature.com
Hydrogel is a type of versatile platform with various biomedical applications after rational
structure and functional design that leverages on material engineering to modulate its …
structure and functional design that leverages on material engineering to modulate its …
Significance of mechanical loading in bone fracture healing, bone regeneration, and vascularization
In 1892, JL Wolff proposed that bone could respond to mechanical and biophysical stimuli
as a dynamic organ. This theory presents a unique opportunity for investigations on bone …
as a dynamic organ. This theory presents a unique opportunity for investigations on bone …
Piezo1/2 mediate mechanotransduction essential for bone formation through concerted activation of NFAT-YAP1-ß-catenin
Mechanical forces are fundamental regulators of cell behaviors. However, molecular
regulation of mechanotransduction remain poorly understood. Here, we identified the …
regulation of mechanotransduction remain poorly understood. Here, we identified the …
[HTML][HTML] Biomaterial-induced pathway modulation for bone regeneration
Embryogenic developmental processes involve a tightly controlled regulation between
mechanical forces and biochemical cues such as growth factors, matrix proteins, and …
mechanical forces and biochemical cues such as growth factors, matrix proteins, and …
Role of YAP/TAZ in cell lineage fate determination and related signaling pathways
BC Heng, X Zhang, D Aubel, Y Bai, X Li… - Frontiers in cell and …, 2020 - frontiersin.org
The penultimate effectors of the Hippo signaling pathways YAP and TAZ, are transcriptional
co-activator proteins that play key roles in many diverse biological processes, ranging from …
co-activator proteins that play key roles in many diverse biological processes, ranging from …
Macrophage K63-linked ubiquitination of YAP promotes its nuclear localization and exacerbates atherosclerosis
M Liu, M Yan, H Lv, B Wang, X Lv, H Zhang, S Xiang… - Cell reports, 2020 - cell.com
Summary The Hippo/Yes-associated protein (YAP) pathway has pivotal roles in innate
immune responses against pathogens in macrophages. However, the role of YAP in …
immune responses against pathogens in macrophages. However, the role of YAP in …
[HTML][HTML] Mechanosensitive Piezo1 is crucial for periosteal stem cell-mediated fracture healing
Y Liu, H Tian, Y Hu, Y Cao, H Song, S Lan… - … Journal of Biological …, 2022 - ncbi.nlm.nih.gov
The biomechanical environment plays a dominant role in fracture healing, and Piezo1 is
regarded as a major mechanosensor in bone homeostasis. However, the role of Piezo1 in …
regarded as a major mechanosensor in bone homeostasis. However, the role of Piezo1 in …
Roles of non-canonical Wnt signalling pathways in bone biology
J Lojk, J Marc - International journal of molecular sciences, 2021 - mdpi.com
The Wnt signalling pathway is one of the central signalling pathways in bone development,
homeostasis and regulation of bone mineral density. It consists of numerous Wnt ligands …
homeostasis and regulation of bone mineral density. It consists of numerous Wnt ligands …
Runx1 is a key regulator of articular cartilage homeostasis by orchestrating YAP, TGFβ, and Wnt signaling in articular cartilage formation and osteoarthritis
Runt-related transcription factor 1 (Runx1) plays a key role in cartilage formation, but its
function in articular cartilage formation is unclear. We generated non-inducible and …
function in articular cartilage formation is unclear. We generated non-inducible and …
Flexible osteogenic glue as an all‐in‐one solution to assist fracture fixation and healing
J Tang, K Xi, H Chen, L Wang, D Li, Y Xu… - Advanced Functional …, 2021 - Wiley Online Library
Osteogenic glue that reproduces the natural bone composition represents the final frontier of
orthopedic adhesives with the potential to revolutionize surgical strategies against …
orthopedic adhesives with the potential to revolutionize surgical strategies against …