Apathy and motivation: biological basis and drug treatment
Apathy is a disabling syndrome associated with poor functional outcomes that is common
across a broad range of neurological and psychiatric conditions. Currently, there are no …
across a broad range of neurological and psychiatric conditions. Currently, there are no …
[HTML][HTML] Post-stroke neuropsychiatric complications: types, pathogenesis, and therapeutic intervention
J Zhou, Y Fangma, Z Chen, Y Zheng - Aging and disease, 2023 - ncbi.nlm.nih.gov
Almost all stroke survivors suffer physical disabilities and neuropsychiatric disturbances,
which can be briefly divided into post-stroke neurological diseases and post-stroke …
which can be briefly divided into post-stroke neurological diseases and post-stroke …
Association of 24-hour activity pattern phenotypes with depression symptoms and cognitive performance in aging
Importance Evidence regarding the nature and prevalence of 24-hour activity pattern
phenotypes in older adults, especially those related to depression symptoms and cognition …
phenotypes in older adults, especially those related to depression symptoms and cognition …
Negative symptoms and cognitive impairment are associated with distinct motivational deficits in treatment resistant schizophrenia
Background Motivational deficits are a central feature of the negative syndrome in
schizophrenia. They have consistently been associated with reduced willingness to expend …
schizophrenia. They have consistently been associated with reduced willingness to expend …
Heightened effort discounting is a common feature of both apathy and fatigue
M Jurgelis, WB Chong, KJ Atkins, PS Cooper… - Scientific reports, 2021 - nature.com
Apathy and fatigue have distinct aetiologies, yet can manifest in phenotypically similar ways.
In particular, each can give rise to diminished goal-directed behaviour, which is often cited …
In particular, each can give rise to diminished goal-directed behaviour, which is often cited …
[HTML][HTML] Apathy symptoms, physical and cognitive function, health-related quality of life, and mortality in older patients with CKD: a longitudinal observational study
CGN Voorend, M van Buren, NC Berkhout-Byrne… - American Journal of …, 2024 - Elsevier
Rationale & Objective Apathy reflects diminished motivation, goal-directed behavior, and
emotions, as well as less engagement in social interactions. Apathy overlaps with …
emotions, as well as less engagement in social interactions. Apathy overlaps with …
Comparison of functional and structural neural network features in older adults with depression with vs without apathy and association with response to escitalopram …
Importance Apathy is prevalent among individuals with late-life depression and is
associated with poor response to pharmacotherapy, including chronicity and disability …
associated with poor response to pharmacotherapy, including chronicity and disability …
The role of the human hippocampus in decision-making under uncertainty
The role of the hippocampus in decision-making is beginning to be more understood.
Because of its prospective and inferential functions, we hypothesized that it might be …
Because of its prospective and inferential functions, we hypothesized that it might be …
Mechanisms underlying motivational dysfunction in schizophrenia
Y Saleh, I Jarratt-Barnham… - Frontiers in Behavioral …, 2021 - frontiersin.org
Negative symptoms are a debilitating feature of schizophrenia which are often resistant to
pharmacological intervention. The mechanisms underlying them remain poorly understood …
pharmacological intervention. The mechanisms underlying them remain poorly understood …
Prevalence, treatment, and neural correlates of apathy in different forms of dementia: a narrative review
I Parrotta, S Cacciatore, F D'Andrea, M D'Anna… - Neurological …, 2024 - Springer
Objectives The aim of this review is to provide an overview on prevalence and clinical tools
for the diagnosis of apathy, as well as on neurophysiological and neuroimaging findings …
for the diagnosis of apathy, as well as on neurophysiological and neuroimaging findings …