The discovery of several unexpected complex biological roles of hyaluronic acid (HA) has
promoted new research impetus for biologists and, the clinical interest in several fields of …

Hyaluronan (HA) is a linear polysaccharide with disaccharide repeats of d-glucuronic acid
and N-acetyl-d-glucosamine. It is evolutionarily conserved and abundantly expressed in the …

Several polymers of both natural and synthetic origin have been used for a variety of
biomedical applications including pharmaceutical preparations, drug targeting, imaging …

Hyaluronan is a straight chain, glycosaminoglycan polymer of the extracellular matrix
composed of repeating units of the disaccharide [-d-glucuronic acid-β1, 3-N-acetyl-d …

The human genome contains six hyaluronidase-like genes. Three genes (HYAL1, HYAL2
and HYAL3) are clustered on chromosome 3p21. 3, and another two genes (HYAL4 and PH …

Control of self-renewal and differentiation of human ES cells (hESCs) remains a challenge.
This is largely due to the use of culture systems that involve poorly defined animal products …

A new pathway of intermediary metabolism is described involving the catabolism of
hyaluronan. The cell surface hyaluronan receptor, CD44, two hyaluronidases, Hyal-1 and …

Hyaluronan (HA) has an extraordinarily high turnover in physiological tissues, and HA
degradation is accelerated in inflammatory and neoplastic diseases. CD44 (a cell surface …

Background: Hyaluronan, or hyaluronic acid (HA), is the major hydrodynamic nonprotein
component of joint synovial fluid (SF). Its unique viscoelastic properties confer remarkable …

Hyaluronan was first described as the mucus of the vitreous body of the eye (1). Its deduced
structure revealed an acidic glycosaminoglycan made entirely of a repeating disaccharide …