The BH3-only Bim protein is a major determinant for initiating the intrinsic apoptotic pathway
under both physiological and pathophysiological conditions. Tight regulation of its …

Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer, despite
improvements in the clinical trial and diagnosis, HCC still remains high mortality due to the …

BH3-only proteins constitute major proportion of pro-apoptotic members of B-cell lymphoma
2 (Bcl-2) family of apoptotic regulatory proteins and participate in embryonic development …

Radiation-induced intestinal fibrosis (RIF) is a chronic toxicity following radiation, and can be
very difficult to treat. Pirfenidone is a promising anti-fibrotic agent that inhibits fibrosis …

A longitudinal molecular model of the development and progression of nonalcoholic fatty
liver disease (NAFLD) over time is lacking. We have recently validated a high fat/sugar water …

Viruses require host cell metabolic reprogramming to satisfy their replication demands;
however, the mechanism by which the Newcastle disease virus (NDV) remodels nucleotide …

Background Clinical management of allergic diseases has been hampered by the lack of
safe and convenient tests to reliably identify culprit allergens and to closely follow changes …

Muffs and beard (Mb) is a phenotype in chickens where groups of elongated feathers gather
from both sides of the face (muffs) and below the beak (beard). It is an autosomal …

Enforced expression of microRNA-155 (miR-155) in myeloid cells has been shown to have
both oncogenic or tumour-suppressor functions in acute myeloid leukaemia (AML). We …

Neutrophils are innate immune effector cells that traffic from the circulation to extravascular
sites of inflammation. β2 integrins are important mediators of the processes involved in …