We celebrate this year the 50th anniversary of the first electrophysiological recordings of the
gating currents from voltage-dependent ion channels done in 1973. This retrospective tries …

Potassium (K+) channels play vital roles in various physiological functions, including
regulating K+ flow in cell membranes, impacting nervous system signal transduction …

Two KCNA2 variants (p. H310Y and p. H310R) were discovered in paediatric patients with
epilepsy and developmental delay. KCNA2 encodes KV1. 2‐channel subunits, which …

We present near-atomic-resolution cryo-EM structures of the mammalian voltage-gated
potassium channel Kv1. 2 in open, C-type inactivated, toxin-blocked and sodium-bound …

K+ channels enable potassium to flow across the membrane with great selectivity. There are
four K+ channel families: voltage-gated K (Kv), calcium-activated (KCa), inwardly rectifying K …

We report on a heterozygous KCNA2 variant in a child with epilepsy. KCNA2 encodes KV1.
2 subunits, which form homotetrameric potassium channels and participate in …

Voltage-gated potassium channel KV 1.3 inhibitors have been shown to be effective in
preventing T-cell proliferation and activation by affecting intracellular Ca 2+ homeostasis …

G protein-coupled receptors (GPCRs) mediate many signal transduction processes in the
body. The discovery that these receptors are voltage-sensitive has changed our …

The Hv1 proton channel shares striking structural homology with fourth transmembrane
helical segment-type voltage-sensor (VS) domains but manifests distinctive functional …

Ion channels are ubiquitous throughout all forms of life. Potassium channels are even found
in viruses. Every cell must communicate with its surroundings, so all cells have them, and …