Together with core histones, which make up the nucleosome, the linker histone (H1) is one
of the five main histone protein families present in chromatin in eukaryotic cells. H1 binds to …

Histone variants endow chromatin with unique properties and show a specific genomic
distribution that is regulated by specific deposition and removal machineries. These variants …

The linker histone H1 family members are a key component of chromatin and bind to the
nucleosomal core particle around the DNA entry and exit sites. H1 can stabilize both …

Chromatin is important for the regulation of transcription and other functions, yet the diversity
of chromatin composition and the distribution along chromosomes are still poorly …

Histone modifications are key components of chromatin packaging but whether they
constitute a 'code'has been contested. We believe that the central issue is causality: are …

Histone proteins wrap DNA to form nucleosome particles that compact eukaryotic genomes
while still allowing access for cellular processes such as transcription, replication and DNA …

Obesity results from chronic energy surplus and excess lipid storage in white adipose tissue
(WAT). In contrast, brown adipose tissue (BAT) efficiently burns lipids through adaptive …

Nucleosome disruption and replacement are crucial activities that maintain epigenomes, but
these highly dynamic processes have been difficult to study. Here, we describe a direct …

Understanding how the genome is structurally organized as chromatin is essential for
understanding its function. Here, we review recent developments that allowed the …

Through epigenetic modifications, specific long-term phenotypic consequences can arise
from environmental influence on slowly evolving genomic DNA. Heritable epigenetic …