Emerging roles of linker histones in regulating chromatin structure and function
DV Fyodorov, BR Zhou, AI Skoultchi… - Nature reviews Molecular …, 2018 - nature.com
Together with core histones, which make up the nucleosome, the linker histone (H1) is one
of the five main histone protein families present in chromatin in eukaryotic cells. H1 binds to …
of the five main histone protein families present in chromatin in eukaryotic cells. H1 binds to …
Variants of core histones and their roles in cell fate decisions, development and cancer
M Buschbeck, SB Hake - Nature reviews Molecular cell biology, 2017 - nature.com
Histone variants endow chromatin with unique properties and show a specific genomic
distribution that is regulated by specific deposition and removal machineries. These variants …
distribution that is regulated by specific deposition and removal machineries. These variants …
The H1 linker histones: multifunctional proteins beyond the nucleosomal core particle
SP Hergeth, R Schneider - EMBO reports, 2015 - embopress.org
The linker histone H1 family members are a key component of chromatin and bind to the
nucleosomal core particle around the DNA entry and exit sites. H1 can stabilize both …
nucleosomal core particle around the DNA entry and exit sites. H1 can stabilize both …
[HTML][HTML] Systematic protein location mapping reveals five principal chromatin types in Drosophila cells
GJ Filion, JG van Bemmel, U Braunschweig, W Talhout… - Cell, 2010 - cell.com
Chromatin is important for the regulation of transcription and other functions, yet the diversity
of chromatin composition and the distribution along chromosomes are still poorly …
of chromatin composition and the distribution along chromosomes are still poorly …
Histone modification: cause or cog?
S Henikoff, A Shilatifard - Trends in Genetics, 2011 - cell.com
Histone modifications are key components of chromatin packaging but whether they
constitute a 'code'has been contested. We believe that the central issue is causality: are …
constitute a 'code'has been contested. We believe that the central issue is causality: are …
The double face of the histone variant H3. 3
E Szenker, D Ray-Gallet, G Almouzni - Cell research, 2011 - nature.com
Histone proteins wrap DNA to form nucleosome particles that compact eukaryotic genomes
while still allowing access for cellular processes such as transcription, replication and DNA …
while still allowing access for cellular processes such as transcription, replication and DNA …
Cyclooxygenase-2 controls energy homeostasis in mice by de novo recruitment of brown adipocytes
A Vegiopoulos, K Müller-Decker, D Strzoda, I Schmitt… - Science, 2010 - science.org
Obesity results from chronic energy surplus and excess lipid storage in white adipose tissue
(WAT). In contrast, brown adipose tissue (BAT) efficiently burns lipids through adaptive …
(WAT). In contrast, brown adipose tissue (BAT) efficiently burns lipids through adaptive …
Genome-wide kinetics of nucleosome turnover determined by metabolic labeling of histones
RB Deal, JG Henikoff, S Henikoff - Science, 2010 - science.org
Nucleosome disruption and replacement are crucial activities that maintain epigenomes, but
these highly dynamic processes have been difficult to study. Here, we describe a direct …
these highly dynamic processes have been difficult to study. Here, we describe a direct …
Beads on a string—nucleosome array arrangements and folding of the chromatin fiber
Understanding how the genome is structurally organized as chromatin is essential for
understanding its function. Here, we review recent developments that allowed the …
understanding its function. Here, we review recent developments that allowed the …
Basic concepts of epigenetics: impact of environmental signals on gene expression
EA Mazzio, KFA Soliman - Epigenetics, 2012 - Taylor & Francis
Through epigenetic modifications, specific long-term phenotypic consequences can arise
from environmental influence on slowly evolving genomic DNA. Heritable epigenetic …
from environmental influence on slowly evolving genomic DNA. Heritable epigenetic …