Physical stability and dissolution behaviors of amorphous pharmaceutical solids: Role of surface and interface effects

Q Shi, SM Moinuddin, Y Wang, F Ahsan, F Li - International Journal of …, 2022 - Elsevier
Amorphous pharmaceutical solids (APS) are single-or multi-component systems in which
drugs exist in high-energy states with long-range disordered molecular packing. APSs have …

Recent advances in enhancement of dissolution and supersaturation of poorly water-soluble drug in amorphous pharmaceutical solids: A review

Q Shi, F Li, S Yeh, SM Moinuddin, J Xin, J Xu… - Aaps Pharmscitech, 2022 - Springer
Amorphization is one of the most effective pharmaceutical approaches to enhance the
dissolution and oral bioavailability of poorly water-soluble drugs. In recent years, amorphous …

Study of disordered mesoporous silica regarding intrinsic compound affinity to the carrier and drug-accessible surface area

A Niederquell, B Vraníková, M Kuentz - Molecular Pharmaceutics, 2023 - ACS Publications
There is increasing research interest in using mesoporous silica for the delivery of poorly
water-soluble drugs that are stabilized in a noncrystalline form. Most research has been …

Characterization of drugs with good glass formers in loaded-mesoporous silica and its theoretical value relevance with mesopores surface and pore-filling capacity

A Budiman, DL Aulifa - Pharmaceuticals, 2022 - mdpi.com
The incorporation of a drug into mesoporous silica (MPS) is a promising strategy to stabilize
its amorphous form. However, the drug within MPS has shown incomplete release, despite a …

A comparative study of the pharmaceutical properties between amorphous drugs loaded-mesoporous silica and pure amorphous drugs prepared by solvent …

A Budiman, DL Aulifa - Pharmaceuticals, 2022 - mdpi.com
The formulation of poorly water-soluble drugs is one of the main challenges in the
pharmaceutical industry, especially in the development of oral dosage forms. Meanwhile …

Light-responsive mesoporous silica nanoparticles loaded with osmanthus fragrance for improving leather odor

X Hu, M Liu, Y Cheng, J Hu - ACS Applied Nano Materials, 2022 - ACS Publications
Improving the odor quality of leather is of great significance for leather commodities.
However, effectively and mildly released odor on targeted leather is still challenging in the …

A Commentary on Co-Processed API as a Promising Approach to Improve Sustainability for the Pharmaceutical Industry

L Schenck, B Risteen, LM Johnson, A Koynov… - Journal of …, 2024 - Elsevier
Pharmaceutical products represent a meaningful target for sustainability improvement and
emissions reduction. It is proposed here that rethinking the standard, and often linear …

Mesoporous Drug Delivery System: From Physical Properties of Drug in Solid State to Controlled Release

Y Wang, F Li, J Xin, J Xu, G Yu, Q Shi - Molecules, 2023 - mdpi.com
Mesoporous materials, which exhibit great potential in the control of polymorphs and
delivery of poorly water-soluble drugs, have obtained considerable attention in the field of …

Studying the Intermolecular Interactions, Structural Dynamics, and Non-Equilibrium Kinetics of Cilnidipine Infiltrated into Alumina and Silica Pores

A Minecka, M Tarnacka, N Soszka, B Hachuła… - Langmuir, 2022 - ACS Publications
In the present study, the behavior of the calcium channel blocker cilnidipine (CLN) infiltrated
into silica (SiO2) and anodic aluminum oxide (AAO) porous membranes characterized by a …

Practical Aspects of XPS: From Sample Preparation to Spectra Interpretation

DY Zemlyanov - Applications of X-ray Photoelectron Spectroscopy …, 2023 - World Scientific
Nowadays, X-ray photoelectron spectroscopy (XPS) is one of the most widely used surface
characterization techniques in materials science and chemistry, spreading to pharmacy …