Interleukin-5 (IL-5) exerts a central pathogenic role in differentiation, recruitment, survival,
and degranulation of eosinophils. Indeed, during the last years, significant advances have …

Chronic rhinosinusitis with nasal polyps (CRSwNP) is generally associated with eosinophilic
tissue infiltration linked to type 2 inflammation and characterized by elevated levels of …

Despite being the second least represented granulocyte subpopulation in the circulating
blood, eosinophils are receiving a growing interest from the scientific community, due to their …

Approximately 5–10% of asthmatic patients worldwide suffer from severe asthma.
Experimental and clinical studies have demonstrated that IL-13 is an important cytokine in …

Background Severe asthma is a major cause of morbidity. Some patients may benefit from
biological therapies. Most evaluations of these treatments are derived from randomized …

Background Tralokinumab is an anti-interleukin-13 human monoclonal antibody developed
for the treatment of severe, uncontrolled asthma. These clinical trials aimed to assess the …

Background Severe Asthma Network in Italy (SANI) is a registry of patients recruited by
accredited centers on severe asthma. Objective To analyze epidemiological, clinical …

A high-intensity potentially tissue-injuring stimulus generates a homotopic response to
escape the stimulus and is associated with an affective phenotype considered to represent …

Introduction: Thymic stromal lymphopoietin (TSLP) is overexpressed in the airways of severe
asthmatics and is an upstream cytokine that orchestrates inflammatory responses in asthma …

Neutrophils (PMNs) contain and release a powerful arsenal of mediators, including several
granular enzymes, reactive oxygen species (ROS) and neutrophil extracellular traps (NETs) …