Adult tissue stem cells have a pivotal role in tissue maintenance and regeneration
throughout the lifespan of multicellular organisms. Loss of tissue homeostasis during post …

Embryogenic developmental processes involve a tightly controlled regulation between
mechanical forces and biochemical cues such as growth factors, matrix proteins, and …

Intestinal organoids are complex three-dimensional structures that mimic the cell-type
composition and tissue organization of the intestine by recapitulating the self-organizing …

Stem cells give rise to all cells and build the tissue structures in our body, and heterogeneity
and plasticity are the hallmarks of stem cells. Epigenetic modification, which is associated …

Background & Aims Studies are needed to determine the mechanism by which Barrett's
esophagus (BE) progresses to esophageal adenocarcinoma (EAC). Notch signaling …

Cnidarians are> 600 million years old and are considered the sister group of Bilateria based
on numerous molecular phylogenetic studies. Apart from Hydra, the genomes of all major …

The elimination of the cancer stem cell (CSC) population may be required to achieve better
outcomes of cancer therapy. We evaluated stearoyl-CoA desaturase 1 (SCD1) as a novel …

Intestinal organoids are widely applied in stem cell research, regenerative medicine,
toxicology, pharmacology, and host-microbe interactions research. The variability of …

The extracellular matrix (ECM) provides a precise physical and molecular environment for
cell maintenance, self-renewal, and differentiation in the stem cell niche. However, the …

Tissue Forge is an open-source interactive environment for particle-based physics,
chemistry and biology modeling and simulation. Tissue Forge allows users to create …