Cellular and epigenetic drivers of stem cell ageing
Adult tissue stem cells have a pivotal role in tissue maintenance and regeneration
throughout the lifespan of multicellular organisms. Loss of tissue homeostasis during post …
throughout the lifespan of multicellular organisms. Loss of tissue homeostasis during post …
[HTML][HTML] Biomaterial-induced pathway modulation for bone regeneration
Embryogenic developmental processes involve a tightly controlled regulation between
mechanical forces and biochemical cues such as growth factors, matrix proteins, and …
mechanical forces and biochemical cues such as growth factors, matrix proteins, and …
Self-organization and symmetry breaking in intestinal organoid development
Intestinal organoids are complex three-dimensional structures that mimic the cell-type
composition and tissue organization of the intestine by recapitulating the self-organizing …
composition and tissue organization of the intestine by recapitulating the self-organizing …
Stem cells in tissues, organoids, and cancers
X Wang - Cellular and Molecular Life Sciences, 2019 - Springer
Stem cells give rise to all cells and build the tissue structures in our body, and heterogeneity
and plasticity are the hallmarks of stem cells. Epigenetic modification, which is associated …
and plasticity are the hallmarks of stem cells. Epigenetic modification, which is associated …
Notch signaling mediates differentiation in Barrett's esophagus and promotes progression to adenocarcinoma
Background & Aims Studies are needed to determine the mechanism by which Barrett's
esophagus (BE) progresses to esophageal adenocarcinoma (EAC). Notch signaling …
esophagus (BE) progresses to esophageal adenocarcinoma (EAC). Notch signaling …
[HTML][HTML] The Hydra stem cell system–Revisited
TW Holstein - Cells & Development, 2023 - Elsevier
Cnidarians are> 600 million years old and are considered the sister group of Bilateria based
on numerous molecular phylogenetic studies. Apart from Hydra, the genomes of all major …
on numerous molecular phylogenetic studies. Apart from Hydra, the genomes of all major …
Targeting a lipid desaturation enzyme, SCD1, selectively eliminates colon cancer stem cells through the suppression of Wnt and NOTCH signaling
Y Yu, H Kim, SG Choi, JS Yu, JY Lee, H Lee, S Yoon… - Cells, 2021 - mdpi.com
The elimination of the cancer stem cell (CSC) population may be required to achieve better
outcomes of cancer therapy. We evaluated stearoyl-CoA desaturase 1 (SCD1) as a novel …
outcomes of cancer therapy. We evaluated stearoyl-CoA desaturase 1 (SCD1) as a novel …
Live cell imaging of mouse intestinal organoids reveals heterogeneity in their oxygenation
Intestinal organoids are widely applied in stem cell research, regenerative medicine,
toxicology, pharmacology, and host-microbe interactions research. The variability of …
toxicology, pharmacology, and host-microbe interactions research. The variability of …
Collagen IV differentially regulates planarian stem cell potency and lineage progression
A Chan, S Ma, BJ Pearson… - Proceedings of the …, 2021 - National Acad Sciences
The extracellular matrix (ECM) provides a precise physical and molecular environment for
cell maintenance, self-renewal, and differentiation in the stem cell niche. However, the …
cell maintenance, self-renewal, and differentiation in the stem cell niche. However, the …
Tissue forge: interactive biological and biophysics simulation environment
Tissue Forge is an open-source interactive environment for particle-based physics,
chemistry and biology modeling and simulation. Tissue Forge allows users to create …
chemistry and biology modeling and simulation. Tissue Forge allows users to create …