Physiological and pathological roles of lipogenesis
Lipids are essential metabolites, which function as energy sources, structural components
and signalling mediators. Most cells are able to convert carbohydrates into fatty acids, which …
and signalling mediators. Most cells are able to convert carbohydrates into fatty acids, which …
Lipid metabolism in regulation of macrophage functions
J Yan, T Horng - Trends in cell biology, 2020 - cell.com
Macrophages are cells of the innate immune system that regulate the maintenance of tissue
homeostasis, host defense during pathogen infection, and tissue repair in response to tissue …
homeostasis, host defense during pathogen infection, and tissue repair in response to tissue …
The liver as an endocrine organ—linking NAFLD and insulin resistance
MJ Watt, PM Miotto, W De Nardo… - Endocrine …, 2019 - academic.oup.com
The liver is a dynamic organ that plays critical roles in many physiological processes,
including the regulation of systemic glucose and lipid metabolism. Dysfunctional hepatic …
including the regulation of systemic glucose and lipid metabolism. Dysfunctional hepatic …
The macrophage-osteoclast axis in osteoimmunity and osteo-related diseases
Y Yao, X Cai, F Ren, Y Ye, F Wang, C Zheng… - Frontiers in …, 2021 - frontiersin.org
Osteoimmunity is involved in regulating the balance of bone remodeling and resorption, and
is essential for maintaining normal bone morphology. The interaction between immune cells …
is essential for maintaining normal bone morphology. The interaction between immune cells …
Adipose tissue macrophage in obesity-associated metabolic diseases
Adipose tissue macrophage (ATM) has been appreciated for its critical contribution to
obesity-associated metabolic diseases in recent years. Here, we discuss the regulation of …
obesity-associated metabolic diseases in recent years. Here, we discuss the regulation of …
Emerging evidence of pathological roles of very-low-density lipoprotein (VLDL)
JK Huang, HC Lee - International journal of molecular sciences, 2022 - mdpi.com
Embraced with apolipoproteins (Apo) B and Apo E, triglyceride-enriched very-low-density
lipoprotein (VLDL) is secreted by the liver into circulation, mainly during post-meal hours …
lipoprotein (VLDL) is secreted by the liver into circulation, mainly during post-meal hours …
[HTML][HTML] Glutamine metabolism in macrophages: a novel target for obesity/type 2 diabetes
Obesity is a nutritional disorder resulting from a chronic imbalance between energy intake
and expenditure. This disease is characterized by inflammation in multiple cell types …
and expenditure. This disease is characterized by inflammation in multiple cell types …
Mechanisms of macrophage polarization in insulin signaling and sensitivity
L Orliaguet, E Dalmas, K Drareni, N Venteclef… - Frontiers in …, 2020 - frontiersin.org
Type-2 diabetes (T2D) is a disease of two etiologies: metabolic and inflammatory. At the
cross-section of these etiologies lays the phenomenon of metabolic inflammation. Whilst …
cross-section of these etiologies lays the phenomenon of metabolic inflammation. Whilst …
Inflammatory mechanisms of diabetes and its vascular complications
LV Nedosugova, YV Markina, LA Bochkareva… - Biomedicines, 2022 - mdpi.com
The main cause of death in patients with type 2 DM is cardiovascular complications resulting
from the progression of atherosclerosis. The pathophysiology of the association between …
from the progression of atherosclerosis. The pathophysiology of the association between …
Structural diversity, hypothetical biosynthesis, chemical synthesis, and biological activity of Ganoderma meroterpenoids
XR Peng, SB Unsicker, J Gershenzon… - Natural Product …, 2023 - pubs.rsc.org
Covering: 2018 to 2022 Meroterpenoids found in fungal species of the genus Ganoderma
and known as Ganoderma meroterpenoids (GMs) are substances composed of a 1, 2, 4 …
and known as Ganoderma meroterpenoids (GMs) are substances composed of a 1, 2, 4 …