Physiological and pathological roles of lipogenesis

YG Jeon, YY Kim, G Lee, JB Kim - Nature Metabolism, 2023 - nature.com
Lipids are essential metabolites, which function as energy sources, structural components
and signalling mediators. Most cells are able to convert carbohydrates into fatty acids, which …

Lipid metabolism in regulation of macrophage functions

J Yan, T Horng - Trends in cell biology, 2020 - cell.com
Macrophages are cells of the innate immune system that regulate the maintenance of tissue
homeostasis, host defense during pathogen infection, and tissue repair in response to tissue …

The liver as an endocrine organ—linking NAFLD and insulin resistance

MJ Watt, PM Miotto, W De Nardo… - Endocrine …, 2019 - academic.oup.com
The liver is a dynamic organ that plays critical roles in many physiological processes,
including the regulation of systemic glucose and lipid metabolism. Dysfunctional hepatic …

The macrophage-osteoclast axis in osteoimmunity and osteo-related diseases

Y Yao, X Cai, F Ren, Y Ye, F Wang, C Zheng… - Frontiers in …, 2021 - frontiersin.org
Osteoimmunity is involved in regulating the balance of bone remodeling and resorption, and
is essential for maintaining normal bone morphology. The interaction between immune cells …

Adipose tissue macrophage in obesity-associated metabolic diseases

J Yao, D Wu, Y Qiu - Frontiers in immunology, 2022 - frontiersin.org
Adipose tissue macrophage (ATM) has been appreciated for its critical contribution to
obesity-associated metabolic diseases in recent years. Here, we discuss the regulation of …

Emerging evidence of pathological roles of very-low-density lipoprotein (VLDL)

JK Huang, HC Lee - International journal of molecular sciences, 2022 - mdpi.com
Embraced with apolipoproteins (Apo) B and Apo E, triglyceride-enriched very-low-density
lipoprotein (VLDL) is secreted by the liver into circulation, mainly during post-meal hours …

[HTML][HTML] Glutamine metabolism in macrophages: a novel target for obesity/type 2 diabetes

W Ren, Y Xia, S Chen, G Wu, FW Bazer, B Zhou… - Advances in …, 2019 - Elsevier
Obesity is a nutritional disorder resulting from a chronic imbalance between energy intake
and expenditure. This disease is characterized by inflammation in multiple cell types …

Mechanisms of macrophage polarization in insulin signaling and sensitivity

L Orliaguet, E Dalmas, K Drareni, N Venteclef… - Frontiers in …, 2020 - frontiersin.org
Type-2 diabetes (T2D) is a disease of two etiologies: metabolic and inflammatory. At the
cross-section of these etiologies lays the phenomenon of metabolic inflammation. Whilst …

Inflammatory mechanisms of diabetes and its vascular complications

LV Nedosugova, YV Markina, LA Bochkareva… - Biomedicines, 2022 - mdpi.com
The main cause of death in patients with type 2 DM is cardiovascular complications resulting
from the progression of atherosclerosis. The pathophysiology of the association between …

Structural diversity, hypothetical biosynthesis, chemical synthesis, and biological activity of Ganoderma meroterpenoids

XR Peng, SB Unsicker, J Gershenzon… - Natural Product …, 2023 - pubs.rsc.org
Covering: 2018 to 2022 Meroterpenoids found in fungal species of the genus Ganoderma
and known as Ganoderma meroterpenoids (GMs) are substances composed of a 1, 2, 4 …