Elucidation of the physiologically distinct subunits of troponin in 1973 greatly facilitated our
understanding of cardiac contraction. Although troponins are expressed in both skeletal and …

It has been known for 50 years that transaminase activity increases in patients with acute
myocardial infarction. With the development of creatine kinase (CK), biomarkers of cardiac …

Contractile and energetic properties of human skeletal muscle have been studied for many
years in vivo in the body. It has been, however, difficult to identify the specific role of muscle …

To improve the specificity of biochemical markers of myocardial infarction (MI), we have
developed a double monoclonal" sandwich" enzyme immunoassay to measure cardiac …

Abstract Cardiac troponin (Tn) I (CTnI), compared with skeletal TnI, contains extra amino
acids (32 to 33) at its amino terminus, including two adjacent serine residues. These two …

The cardiac troponins form part of the regulatory mechanism for muscle contraction. Specific
cardiac isoforms of cardiac troponin T and cardiac troponin I exist and commercially …

Cardiovascular disease (CVD) has threatened human lives for decades, and a technique for
estimating and healing is still needed. There has been increasing interest in finding CVD …

During heart development, chamber myocardium forms locally from the embryonic
myocardium of the tubular heart. The atrial natriuretic factor (ANF) gene is specifically …

Chemiluminescence (CL) immunoassays for simultaneous detection of early acute
myocardial infarction (AMI) biomarkers, including copeptin, heart-type fatty acid binding …

Recent reports have demonstrated the presence of two isoforms of troponin I in the human
fetal heart, namely, cardiac troponin I and slow skeletal muscle troponin I. Structural and …