Dendritic cells (DCs) are the key link between innate immunity and adaptive immunity and
play crucial roles in both the promotion of immune defense and the maintenance of immune …

G‐protein–coupled receptor (GPCR) signaling is essential for the spatiotemporal control of
leukocyte dynamics during immune responses. For efficient navigation through mammalian …

Immune responses rely on the rapid and coordinated migration of leukocytes. Whereas it is
well established that single-cell migration is often guided by gradients of chemokines and …

Chemokines are pivotal regulators of cell migration during continuous immune surveillance,
inflammation, homeostasis, and development. Chemokine binding to their 7-transmembrane …

CCR7, collaborated with its ligands CCL19 and CCL21, controls extensive migratory events
in the immune system. CCR7-bearing dendritic cells can swarm into T-cell zones in lymph …

A prominent activity of the chemokine system is the regulation of leukocyte trafficking. Here
we summarize recent findings on the initial steps in chemokine receptor–induced signal …

CCL19 and CCL21 are endogenous agonists for the seven-transmembrane receptor CCR7.
They are equally active in promoting G protein stimulation and chemotaxis. Yet, we find that …

Natural killer (NK) cell-based cell therapy has been emerging as a powerful weapon in the
treatment of multiple malignancies. However, the inadequate infiltration of the therapeutic …

Breast cancer is a leading cause of cancer-related deaths worldwide, predominantly caused
by metastasis. It is generally accepted that the pattern of breast cancer metastasis is largely …

Collective cell migration is a widespread biological phenomenon, whereby groups of highly
coordinated, adherent cells move in a polarized fashion [1, 2]. This migration mode is a …