The convergence of tissue engineering and patient-specific stem cell biology has enabled
the engineering of in vitro tissue models that allow the study of patient-tailored treatment …

Cardiovascular disease (CVD), the world's leading cause of death, exhibits notable
epidemiological, clinical, and pathophysiological differences between sexes. Many such …

Studying the function of common genetic variants in primary human tissues and during
development is challenging. To address this, we use an efficient multiplexing strategy to …

Transcriptional enhancers direct precise gene expression patterns during development and
harbor the majority of variants associated with phenotypic diversity, evolutionary …

Summary The Foundational Data Initiative for Parkinson Disease (FOUNDIN-PD) is an
international collaboration producing fundamental resources for Parkinson disease (PD) …

Stem cells exist in vitro in a spectrum of interconvertible pluripotent states. Analyzing
hundreds of hiPSCs derived from different individuals, we show the proportions of these …

Dynamic and temporally specific gene regulatory changes may underlie unexplained
genetic associations with complex disease. During a dynamic process such as cellular …

Reactivation of fetal-specific genes and isoforms occurs during heart failure. However, the
underlying molecular mechanisms and the extent to which the fetal program switch occurs …

Intracellular access with high spatiotemporal resolution can enhance the understanding of
how neurons or cardiomyocytes regulate and orchestrate network activity and how this …

Doxorubicin is a potent anticancer drug used to treat a variety of cancer types. However, its
use is limited by doxorubicin-induced cardiotoxicity (DIC). A missense variant in the RARG …