[HTML][HTML] FLASH radiotherapy combined with immunotherapy: From biological mechanisms to blockbuster therapeutics

Y Wang, SN Qi, N Bi, YX Li - Translational Oncology, 2025 - Elsevier
FLASH ultra-high dose rate radiotherapy (RT) can effectively exert the protective effect on
normal tissue and reduce the risk of treatment-related toxicity, without compromising the …

[HTML][HTML] FLASH Radiotherapy: A FLASHing Idea to Preserve Neurocognitive Function

HJ Jo, T Oh, YR Lee, GS Kang, HJ Park… - Brain Tumor Research …, 2023 - ncbi.nlm.nih.gov
Abstract FLASH radiotherapy (FLASH RT) is a technique to deliver ultra-high dose rate in a
fraction of a second. Evidence from experimental animal models suggest that FLASH RT …

The effect of electron backscatter and charge build up in media on beam current transformer signal for ultra-high dose rate (FLASH) electron beam monitoring

C Pageot, K Zerouali, D Guillet, B Muir… - Physics in Medicine …, 2024 - iopscience.iop.org
Objective. Beam current transformers (BCT) are promising detectors for real-time beam
monitoring in ultra-high dose rate (UHDR) electron radiotherapy. However, previous studies …

[HTML][HTML] Impact of Scattering Foil Composition on Electron Energy Distribution in a Clinical Linear Accelerator Modified for FLASH Radiotherapy: A Monte Carlo Study

JCL Chow, HE Ruda - Materials, 2024 - mdpi.com
This study investigates how scattering foil materials and sampling holder placement affect
electron energy distribution in electron beams from a modified medical linear accelerator for …

Electron FLASH platform for pre-clinical research: LINAC modification, simplification of pulse control and dosimetry

B Zhou, L Guo, W Lu, M Rahman, R Zhang… - arXiv preprint arXiv …, 2024 - arxiv.org
Background: FLASH radiotherapy is a treatment regime that delivers therapeutic dose to
tumors at an ultra-high dose rate while maintaining adequate normal tissue sparing …

Dosimetric calibration of anatomy‐specific ultra‐high dose rate electron irradiation platform for preclinical FLASH radiobiology experiments

J Wang, S Melemenidis, R Manjappa… - Medical …, 2024 - Wiley Online Library
Background FLASH radiation therapy (RT) offers a promising avenue for the broadening of
the therapeutic index. However, to leverage the full potential of FLASH in the clinical setting …

Mimicking large spot‐scanning radiation fields for proton FLASH preclinical studies with a robotic motion platform

F Guan, D Jiang, X Wang, M Yang, K Iga… - Precision Radiation …, 2024 - Wiley Online Library
Previously, a synchrotron‐based horizontal proton beamline (87.2 MeV) was successfully
commissioned to deliver radiation doses in FLASH and conventional dose rate modes to …