The landscape of mRNA nanomedicine
Messenger RNA (mRNA) is an emerging class of therapeutic agent for the prevention and
treatment of a wide range of diseases. The recent success of the two highly efficacious …
treatment of a wide range of diseases. The recent success of the two highly efficacious …
Advances in COVID-19 mRNA vaccine development
E Fang, X Liu, M Li, Z Zhang, L Song, B Zhu… - Signal transduction and …, 2022 - nature.com
To date, the coronavirus disease 2019 (COVID-19) caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) has determined 399,600,607 cases and 5,757,562 …
syndrome coronavirus 2 (SARS-CoV-2) has determined 399,600,607 cases and 5,757,562 …
Immunological mechanisms of vaccine-induced protection against COVID-19 in humans
M Sadarangani, A Marchant… - Nature Reviews …, 2021 - nature.com
Most COVID-19 vaccines are designed to elicit immune responses, ideally neutralizing
antibodies (NAbs), against the SARS-CoV-2 spike protein. Several vaccines, including …
antibodies (NAbs), against the SARS-CoV-2 spike protein. Several vaccines, including …
Nanomaterial delivery systems for mRNA vaccines
The recent success of mRNA vaccines in SARS-CoV-2 clinical trials is in part due to the
development of lipid nanoparticle delivery systems that not only efficiently express the …
development of lipid nanoparticle delivery systems that not only efficiently express the …
COVID-19 mRNA vaccines: Platforms and current developments
GT Szabó, AJ Mahiny, I Vlatkovic - Molecular Therapy, 2022 - cell.com
Since the first successful application of messenger ribonucleic acid (mRNA) as a vaccine
agent in a preclinical study nearly 30 years ago, numerous advances have been made in …
agent in a preclinical study nearly 30 years ago, numerous advances have been made in …
Opportunities and challenges in the delivery of mRNA-based vaccines
In the past few years, there has been increasing focus on the use of messenger RNA
(mRNA) as a new therapeutic modality. Current clinical efforts encompassing mRNA-based …
(mRNA) as a new therapeutic modality. Current clinical efforts encompassing mRNA-based …
Tailoring mRNA vaccine to balance innate/adaptive immune response
S Linares-Fernández, C Lacroix, JY Exposito… - Trends in molecular …, 2020 - cell.com
mRNA vaccine platforms present numerous advantages, such as versatility, rapid
production, and induction of cellular and humoral responses. Moreover, mRNAs have …
production, and induction of cellular and humoral responses. Moreover, mRNAs have …
Three decades of messenger RNA vaccine development
R Verbeke, I Lentacker, SC De Smedt, H Dewitte - Nano Today, 2019 - Elsevier
In the early nineties, pioneering steps were taken in the use of mRNA as a therapeutic tool
for vaccination. In the following decades, an improved understanding of the mRNA …
for vaccination. In the following decades, an improved understanding of the mRNA …
Impact of mRNA chemistry and manufacturing process on innate immune activation
J Nelson, EW Sorensen, S Mintri, AE Rabideau… - Science …, 2020 - science.org
Messenger RNA (mRNA) represents an attractive therapeutic modality for potentially a wide
range of clinical indications but requires uridine chemistry modification and/or tuning of the …
range of clinical indications but requires uridine chemistry modification and/or tuning of the …
[HTML][HTML] Engineering of the current nucleoside-modified mRNA-LNP vaccines against SARS-CoV-2
JT Granados-Riveron, G Aquino-Jarquin - Biomedicine & Pharmacotherapy, 2021 - Elsevier
Currently, there are over 230 different COVID-19 vaccines under development around the
world. At least three decades of scientific development in RNA biology, immunology …
world. At least three decades of scientific development in RNA biology, immunology …