Human cohesin compacts DNA by loop extrusion
Cohesin is a chromosome-bound, multisubunit adenosine triphosphatase complex. After
loading onto chromosomes, it generates loops to regulate chromosome functions. It has …
loading onto chromosomes, it generates loops to regulate chromosome functions. It has …
Compartmentalization of telomeres through DNA-scaffolded phase separation
Telomeres form unique nuclear compartments that prevent degradation and fusion of
chromosome ends by recruiting shelterin proteins and regulating access of DNA damage …
chromosome ends by recruiting shelterin proteins and regulating access of DNA damage …
Large-scale preparation of fluorescence multiplex host cell reactivation (FM-HCR) reporters
Repair of DNA damage is a critical survival mechanism that affects susceptibility to various
human diseases and represents a key target for cancer therapy. A major barrier to applying …
human diseases and represents a key target for cancer therapy. A major barrier to applying …
ssDNA accessibility of Rad51 is regulated by orchestrating multiple RPA dynamics
The eukaryotic single-stranded DNA (ssDNA)-binding protein Replication Protein A (RPA)
plays a crucial role in various DNA metabolic pathways, including DNA replication and …
plays a crucial role in various DNA metabolic pathways, including DNA replication and …
[HTML][HTML] Condensation goes viral: a polymer physics perspective
The past decade has seen a revolution in our understanding of how the cellular environment
is organized, where an incredible body of work has provided new insights into the role …
is organized, where an incredible body of work has provided new insights into the role …
How glutamate promotes liquid-liquid phase separation and DNA binding cooperativity of E. coli SSB protein
E. coli single-stranded-DNA binding protein (EcSSB) displays nearest-neighbor (NN) and
non-nearest-neighbor (NNN)) cooperativity in binding ssDNA during genome maintenance …
non-nearest-neighbor (NNN)) cooperativity in binding ssDNA during genome maintenance …
Polymerase theta-helicase promotes end joining by stripping single-stranded DNA-binding proteins and bridging DNA ends
Homologous recombination-deficient cancers rely on DNA polymerase Theta (Polθ)-
Mediated End Joining (TMEJ), an alternative double-strand break repair pathway. Polθ is …
Mediated End Joining (TMEJ), an alternative double-strand break repair pathway. Polθ is …
[HTML][HTML] PARP1 condensates differentially partition DNA repair proteins and enhance DNA ligation
CC Sang, G Moore, M Tereshchenko, H Zhang… - EMBO …, 2024 - pmc.ncbi.nlm.nih.gov
Poly (ADP-ribose) polymerase 1 (PARP1) is one of the first responders to DNA damage and
plays crucial roles in recruiting DNA repair proteins through its activity–poly (ADP-ribosyl) …
plays crucial roles in recruiting DNA repair proteins through its activity–poly (ADP-ribosyl) …
Regulation of nearest-neighbor cooperative binding of E. coli SSB protein to DNA
Escherichia coli single-strand (ss) DNA-binding protein (SSB) is an essential protein that
binds ssDNA intermediates formed during genome maintenance. SSB homotetramers bind …
binds ssDNA intermediates formed during genome maintenance. SSB homotetramers bind …
RADX condenses single-stranded DNA to antagonize RAD51 loading
RADX is a mammalian single-stranded DNA-binding protein that stabilizes telomeres and
stalled replication forks. Cellular biology studies have shown that the balance between …
stalled replication forks. Cellular biology studies have shown that the balance between …