Currently, there are at least 70 pure domestic pig breeds, but only certain breeds are used in
biomedical research. The domestic pig liver is suitable for preclinical research because its …

Hydrodynamic gene delivery has proven to be a safe and efficient procedure for gene
transfer, able to mediate, in murine model, therapeutic levels of proteins encoded by the …

Evidence in support of safety of a gene delivery procedure is essential toward gene therapy.
Previous studies using the hydrodynamics-based procedure primarily focus on gene …

In teaching and learning human anatomy, anatomical autopsy and prosected specimens
have always been indispensable. However, alternative methods must often be used to …

Although calcineurin inhibitors are very effective as immunosuppressants in organ
transplantation, complete graft acceptance remains as a challenge. Transfer of genes with …

Introduction Expressing exogenous genes after naked DNA delivery into hepatocytes might
achieve sustained and high expression of human proteins. Tail vein DNA injection is an …

Enrofloxacin (ENR) and roxarsone (ROX) have been widely used in animal breeding. In this
study, the daily clinical dosage of ENR and daily additive amount of ROX were administrated …

Different diseases lead, during their advanced stages, to chronic or acute liver failure, whose
unique treatment consists in organ transplantation. The success of intervention is limited by …

Hydrodynamic gene delivery is a common method for gene transfer to the liver of small
animals, and its clinical applicability in large animals has been demonstrated. Previous …

Development of an effective, safe, and convenient method for gene delivery to the pancreas
is a critical step toward gene therapy for pancreatic diseases. Therefore, we tested the …