Degradation of mitochondria via a selective form of autophagy, named mitophagy, is a
fundamental mechanism conserved from yeast to humans that regulates mitochondrial …

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) primarily affect the
motor and frontotemporal areas of the brain, respectively. These disorders share clinical …

The efficient study of human disease requires the proper tools, one of the most crucial of
which is an accurate animal model that faithfully recapitulates the human condition. The …

Objectives Recent advances in amyotrophic lateral sclerosis (ALS) genetics have revealed
that mutations in any of more than 25 genes can cause ALS, mostly as an autosomal …

Frontotemporal lobar degeneration (FTLD) represents a group of neurodegenerative brain
diseases with highly heterogeneous clinical, neuropathological and genetic characteristics …

Mutations in TANK binding kinase 1 (TBK1) have been linked to amyotrophic lateral
sclerosis. Some TBK1 variants are nonsense and are predicted to cause disease through …

Amyotrophic lateral sclerosis and frontotemporal dementia are two progressive, adult onset
neurodegenerative diseases, caused by the cell death of motor neurons in the motor cortex …

Mitophagy is one of the selective autophagy pathways that catabolizes dysfunctional or
superfluous mitochondria. Under mitophagy‐inducing conditions, mitochondria are labeled …

Mutations in the Tank-binding kinase 1 (TBK1) gene were identified in 2015 in individuals
with frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS) …

Mutations in the TBK1 (TANK binding kinase 1) gene are causally linked to amyotrophic
lateral sclerosis (ALS) and frontotemporal dementia (FTD). TBK1 phosphorylates the cargo …