Being responsible for more than 90% of cellular functions, protein molecules are workhorses
in all the life forms. In order to cater for such a high demand, proteins have evolved to adopt …

Wound healing, particularly for chronic wounds, presents a considerable difficulty due to
differences in biochemical and cellular processes that occur in different types of wounds …

TAR DNA-binding protein 43 (TDP-43) has emerged as a key player in many
neurodegenerative pathologies, including frontotemporal lobar degeneration (FTLD) and …

Biomolecular condensates (BCs) are membraneless hubs enriched with proteins and
nucleic acids that have emerged as important players in many cellular functions. Uncovering …

Granulins are conserved in nearly all metazoans, with an intriguing loss in insects. These
pleiotropic peptides are involved in numerous physiological and pathological processes yet …

Oligomers of amyloid-β (Aβ) have emerged as the primary toxic agents responsible for early
synaptic dysfunction and neuronal death in Alzheimer's disease (AD). Characterization of …

Granulins are a family of growth factors involved in cell proliferation. The liver-fluke granulin,
Ov-GRN-1, isolated from a carcinogenic liver fluke Opisthorchis viverrini, can significantly …

Granulins (GRNs) are a family of small (∼ 6 kDa) proteins generated by the proteolytic
processing of their precursor, progranulin (PGRN), in many cell types. Both PGRN and …

Abstract Granulins (GRN 1‐7) are short (~ 6 kDa), cysteine‐rich proteins that are generated
upon the proteolytic processing of progranulin (PGRN). These peptides, along with their …

Abstract Granulins (GRNs 1–7) are cysteine-rich proteolytic products of progranulin (PGRN)
that have recently been implicated in neurodegenerative diseases including frontotemporal …