Rho GTPases are a family of small G proteins that regulate a wide array of cellular
processes related to their key roles controlling the cytoskeleton. Cancer is a multistep …

As key regulators of cytoskeletal dynamics, Rho GTPases coordinate a wide range of
cellular processes, including cell polarity, cell migration, and cell cycle progression. The …

Small-molecule chemical probes or tools have become progressively more important in
recent years as valuable reagents to investigate fundamental biological mechanisms and …

Malignant carcinomas are often characterized by metastasis, the movement of carcinoma
cells from a primary site to colonize distant organs. For metastasis to occur, carcinoma cells …

Abstract The p21-Activated kinase 1 (PAK1), a member of serine-threonine kinases family,
was initially identified as an interactor of the Rho GTPases RAC1 and CDC42, which affect a …

Acetals and ketals and their nitrogen and sulfur homologues are often considered to be
unconventional and potentially problematic scaffolding elements or pharmacophores for the …

Salt-inducible kinases (SIKs), which comprise a family of three homologous serine-threonine
kinases, were first described for their role in sodium sensing but have since been shown to …

p21-Activated kinase 1 (PAK1) has attracted much attention as a potential therapeutic target
due to its central role in many oncogenic signaling pathways, its frequent dysregulation in …

Survivin, a homodimeric protein and a member of the IAP family, plays a vital function in cell
survival and cycle progression by interacting with various proteins and complexes. Its …

Triple-negative breast cancer (TNBC) is the most poorly treated subtype of breast cancer,
and targeting the heterogeneity of TNBC has emerged as a fascinating therapeutic strategy …