Telomeres, the ends of linear eukaryotic chromosomes, are characterized by the presence
of multiple repeats of a short DNA sequence. This telomeric DNA is protected from illicit …

The structure and integrity of telomeres are essential for genome stability. Telomere
dysregulation can lead to cell death, cell senescence, or abnormal cell proliferation. The …

Telomerase is the enzyme responsible for maintenance of the length of telomeres by
addition of guanine-rich repetitive sequences. Telomerase activity is exhibited in gametes …

Chromosome stability requires a dynamic balance of DNA loss and gain in each terminal
tract of telomeric repeats. Repeat addition by a specialized reverse transcriptase …

Abstract The Nobel Prize in Physiology or Medicine was recently awarded to Elizabeth
Blackburn, Carol Greider and Jack Szostak for their pioneering studies on chromosome …

Telomeres are the physical ends of eukaryotic linear chromosomes. Telomeres form special
structures that cap chromosome ends to prevent degradation by nucleolytic attack and to …

Telomerase, a ribonucleoprotein enzyme, adds telomeric DNA repeats to the ends of linear
chromosomes. Here we report the first high-resolution structure of any portion of the …

The vast body of literature regarding human telomere maintenance is a true testament to the
importance of understanding telomere regulation in both normal and diseased states. In this …

RNA–protein interactions are vitally important in a wide range of biological processes,
including regulation of gene expression, protein synthesis, and replication and assembly of …

Eukaryotic chromosome maintenance requires telomeric repeat synthesis by telomerase. It
remains uncertain how telomerase domains interact to organize the active RNP and how …