This review provides a comprehensive and updated overview of the state of the art related to
the biomedical applications of nanoparticles coated with chitosan. Discussions were based …

Cancer is one of the main causes of death globally and considered as a major challenge for
the public health system. The high toxicity and the lack of selectivity of conventional …

Bromelain is a key enzyme found in pineapple (Ananas comosus (L.) Merr.); a proteolytic
substance with multiple beneficial effects for human health such as anti-inflammatory …

Chitosan-based particles are widely proposed as biocompatible drug delivery systems with
mucoadhesive and permeation enhancing properties. However, strategies on how to …

The degradation of extracellular matrix (ECM) to increase drug permeability is an attractive
approach to enhancing pancreatic cancer therapy efficiency. Herein, polypyrrole …

Dense extracellular matrix (ECM) is a primary obstacle that restrains the permeation of
therapeutic drugs in tumor tissues. Degrading ECM with bromelain (Br) to increase drug …

Stem bromelain is a common available cysteine protease derived from pineapple (Ananas
comosus L.). Bromelain finds widespread applications in several areas, such as medicine …

Bromelain (Br), a mixture of proteolytic enzymes from pineapple (Ananas comosus), has
various therapeutic potentials; however, its low bioavailability has limited the clinical …

Tumor extracellular matrix (ECM) still remains a major barrier that hinders the diffusion of
drug in tumor parenchyma. We design a lactobionic acid (LA) and bromelain dual-functional …

Bromelain has many therapeutic properties including wound healing and blood circulation
improvement. However, bromelain is usually unstable and suffers autolysis, which results in …