Importance The etiologic factors of late-life depression are still poorly understood. Recent
evidence suggests that microvascular dysfunction is associated with depression, which may …

Neurodegenerative diseases are a group of pathologies that cause severe disability due to
motor and cognitive limitations. In particular, cognitive impairment is a growing health and …

Cerebral small vessel disease (CSVD) refers to a spectrum of clinical and imaging findings
resulting from pathological processes of various etiologies affecting cerebral arterioles …

Intracranial and extracranial arterial stenosis, the primary cause of chronic cerebral
hypoperfusion (CCH), is a critical reason for the pathogenesis of vascular dementia and …

Background Brain circulation disorders such as chronic cerebral hypoperfusion have been
associated with a decline in cognitive function during the development of dementia …

Toxoplasmosis is one of the leading parasitic diseases worldwide. Some data suggest that
chronic acquired toxoplasmosis could be linked to behavioral alterations in humans. The …

OBJECTIVE The cognitive deficits of vascular dementia and the vasoocclusive state of
moyamoya disease have often been mimicked with bilateral stenosis/occlusion of the …

Vascular cognitive impairment and dementia (VCID) are a growing threat to public health
without any known treatment. The bilateral common carotid artery stenosis (BCAS) mouse …

Rationale: Physical exercise is an essential adjunct to the management of patients with type
2 diabetes mellitus. Therapeutic interventions that improve blood flow to peripheral nerves …

Background Vascular dementia (VaD) mainly results from cerebral vascular lesions and
tissue changes, which contribute to neurodegenerative processes. Effective therapeutic …