The basic-helix/loop/helix per-Arnt-sim (bHLH/PAS) family comprises many transcription
factors, found throughout all three kingdoms of life; bHLH/PAS members “sense” …

SUMMARY PAS domains are newly recognized signaling domains that are widely
distributed in proteins from members of the Archaea and Bacteria and from fungi, plants …

Transcriptional enhancers are crucial regulators of gene expression and animal
development and the characterization of their genomic organization, spatiotemporal …

Hypoxia-inducible factor 1 (HIF-1) is found in mammalian cells cultured under reduced O2
tension and is necessary for transcriptional activation mediated by the erythropoietin gene …

Here we describe the cloning and characterization of a PAS domain transcription factor
termed endothelial PAS-1 (EPAS1). This protein shares 48% sequence identity with hypoxia …

We used positional cloning to identify the circadian Clock gene in mice. Clock is a large
transcription unit with 24 exons spanning∼ 100,000 bp of DNA from which transcript classes …

Basic helix–loop–helix (bHLH) transcription factors (TFs) belong to a family of transcriptional
regulators present in three eukaryotic kingdoms. Many different functions have been …

Hypoxia-inducible factor 1 (HIF-1) is a heterodimeric basic helix-loop-helix transcription
factor that regulates hypoxia-inducible genes including the human erythropoietin (EPO) …

Per-ARNT-Sim (PAS) domains serve as versatile sensor and interaction modules in signal
transduction proteins. PAS sensors detect chemical and physical stimuli and regulate the …

We have isolated and characterized a cDNA for a novel Per-Arnt/AhR-Sim basic helix–loop–
helix (bHLH-PAS) factor that interacts with the Ah receptor nuclear translocator (Arnt), and its …