Human noroviruses: recent advances in a 50-year history

RL Atmar, S Ramani, MK Estes - Current opinion in infectious …, 2018 - journals.lww.com
Norovirus epidemiology is complex and requires continued surveillance to track the
emergence of new strains and recombinants, especially with the continued progress in …

Human norovirus proteins: implications in the replicative cycle, pathogenesis, and the host immune response

CP Campillay-Véliz, JJ Carvajal… - Frontiers in …, 2020 - frontiersin.org
Human noroviruses (HuNoVs) are the cause of more than 95% of epidemic non-bacterial
gastroenteritis worldwide, with some lethal cases. These viral agents affect people of all …

Immune imprinting drives human norovirus potential for global spread

LC Lindesmith, FAT Boshier, PD Brewer-Jensen, S Roy… - MBio, 2022 - Am Soc Microbiol
Understanding the complex interactions between virus and host that drive new strain
evolution is key to predicting the emergence potential of variants and informing vaccine …

Genome-wide analyses of human noroviruses provide insights on evolutionary dynamics and evidence of coexisting viral populations evolving under recombination …

K Tohma, CJ Lepore, M Martinez, JI Degiuseppe… - PLoS …, 2021 - journals.plos.org
Norovirus is a major cause of acute gastroenteritis worldwide. Over 30 different genotypes,
mostly from genogroup I (GI) and II (GII), have been shown to infect humans. Despite three …

Understanding the relationship between norovirus diversity and immunity

LA Ford-Siltz, K Tohma, GI Parra - Gut microbes, 2021 - Taylor & Francis
Human noroviruses are the most common viral cause of acute gastroenteritis worldwide.
Currently, there are no approved vaccines or specific therapeutics to treat the disease. Some …

Infant antibody and B-cell responses following confirmed pediatric GII. 17 norovirus infections functionally distinguish GII. 17 genetic clusters

CA Strother, PD Brewer-Jensen… - Frontiers in …, 2023 - frontiersin.org
Genogroup II (GII) noroviruses are a major cause of diarrheal disease burden in children in
both high-and low-income countries. GII. 17 noroviruses are composed of distinct genetic …

The antigenic topology of norovirus as defined by B and T cell epitope mapping: implications for universal vaccines and therapeutics

JM van Loben Sels, KY Green - Viruses, 2019 - mdpi.com
Human norovirus (HuNoV) is the leading cause of acute nonbacterial gastroenteritis.
Vaccine design has been confounded by the antigenic diversity of these viruses and a …

Epidemiological, molecular, and clinical features of norovirus infections among pediatric patients in Qatar

S Mathew, K Alansari, M K. Smatti, H Zaraket… - Viruses, 2019 - mdpi.com
Background: Norovirus (NoV) is recognized as the second most important etiological agent
leading to acute gastroenteritis globally. In order to determine the burden and characteristics …

Identification of a blockade epitope of human norovirus GII. 17

Y Yi, X Wang, S Wang, P Xiong, Q Liu… - Emerging Microbes & …, 2021 - Taylor & Francis
Human noroviruses are the dominant causative agent of acute viral gastroenteritis
worldwide. During the winter of 2014–2015, genotype GII. 17 cluster IIIb strains emerged as …

Antigenic characterization of a novel recombinant GII. P16-GII. 4 Sydney norovirus strain with minor sequence variation leading to antibody escape

LC Lindesmith, PD Brewer-Jensen… - The Journal of …, 2018 - academic.oup.com
Background Human noroviruses are the leading cause of acute gastroenteritis. Strains of the
GII. 4 genotype cause pandemic waves associated with viral evolution and subsequent …